Impacts of Quorum Sensing on Microbial Metabolism and Human Health

被引:36
作者
Yong, Yang-Chun [1 ]
Zhong, Jian-Jiang [2 ]
机构
[1] Jiangsu Univ, Biofuels Inst, Sch,Environm, Zhenjiang 212013, Jiangsu, Peoples R China
[2] Shanghai Jiao Tong Univ, Lab Mol Biochem Engn, State Key Lab Microbial Metab, Sch Life Sci & Biotechnol, 800 Dong Chuan Rd, Shanghai 200240, Peoples R China
来源
FUTURE TRENDS IN BIOTECHNOLOGY | 2013年 / 131卷
基金
中国国家自然科学基金;
关键词
Quorum Sensing; Metabolism; Pathogenesis; Biosensor; Bioenergy; PSEUDOMONAS-AERUGINOSA VIRULENCE; TO-CELL COMMUNICATION; CARBAPENEM ANTIBIOTIC PRODUCTION; ACYL-HOMOSERINE LACTONES; RHAMNOLIPID BIOSURFACTANT SYNTHESIS; LACTIC-ACID BACTERIA; STAPHYLOCOCCUS-AUREUS; VIBRIO-HARVEYI; CYSTIC-FIBROSIS; TRANSCRIPTIONAL ACTIVATOR;
D O I
10.1007/10_2012_138
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Bacteria were considered to be lonely 'mutes' for hundreds of years. However, recently it was found that bacteria usually coordinate their behaviors at the population level by producing (speaking), sensing (listening), and responding to small signal molecules. This so-called quorum sensing (QS) regulation enables bacteria to live in a 'society' with cell-cell communication and controls many important bacterial behaviors. In this chapter, QS systems and their signal molecules for Gram-negative and Gram-positive bacteria are introduced. Most interestingly, QS regulates the important bacterial behaviors such as metabolism and pathogenesis. QS-regulated microbial metabolism includes antibiotic synthesis, pollutant biodegradation, and bioenergy production, which are very relevant to human health. QS is also well-known for its involvement in bacterial pathogenesis, such as iin nfections by Pseudomonas aeruginosa and Staphylococcus aureus. Novel disease diagnosis strategies and antimicrobial agents have also been developed based on QS regulation on bacterial infections. In addition, to meet the requirements for the detection/quantification of QS signaling molecules for research and application, different biosensors have been constructed, which will also be reviewed here. QS regulation is essential to bacterial survival and important to human health. A better understanding of QS could lead better control/manipulation of bacteria, thus making them more helpful to people.
引用
收藏
页码:25 / 61
页数:37
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