Migrastatics-Anti-metastatic and Anti-invasion Drugs: Promises and Challenges

被引：278

作者：

Gandalovicova, Aneta ^{[1
,2
,3
]}

Rosel, Daniel ^{[1
,2
,3
]}

Fernandes, Michael ^{[4
]}

Vesely, Pavel ^{[5
]}

Heneberg, Petr ^{[6
]}

Cermak, Vladimir ^{[1
,2
,3
]}

Petruzelka, Lubos ^{[7
,8
]}

Kumar, Sunil ^{[9
]}

Sanz-Moreno, Victoria ^{[10
]}

Brabek, Jan ^{[1
,2
,3
]}

机构：

[1] Charles Univ Prague, Dept Cell Biol, Vinicna 7, Prague, Czech Republic

[2] Acad Sci, Biotechnol & Biomed Ctr, Prumyslova 595, Vestec U Prahy 25242, Czech Republic

[3] Charles Univ Prague, BIOCEV, Prumyslova 595, Vestec U Prahy 25242, Czech Republic

[4] Medbase, Chapel Hill, NC USA

[5] Brno Univ Technol, Cent European Inst Technol, Brno, Czech Republic

[6] Charles Univ Prague, Dept Internal Med, Fac Med 3, Prague, Czech Republic

[7] Charles Univ Prague, Fac Med 1, Dept Oncol, Prague, Czech Republic

[8] Gen Univ Hosp, Prague, Czech Republic

[9] Ayurveda Mol Modeling, Hyderabad, Telangana, India

[10] Kings Coll London, Randall Div Cell & Mol Biophys, Tumor Plast Lab, Guys Campus, London, England

来源：

TRENDS IN CANCER | 2017年 / 3卷 / 06期

关键词：

RHO-KINASE INHIBITOR; CANCER-CELL INVASION; CYTOCHALASIN-B; ACTIN CYTOSKELETON; PROTEIN-KINASE; NATURAL-PRODUCT; HEPATOCELLULAR-CARCINOMA; MOLECULAR-MECHANISMS; SIGNALING COOPERATE; GASTRIC-CARCINOMA;

D O I：

10.1016/j.trecan.2017.04.008

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing. Here, we coin the term 'migrastatics' for drugs interfering with all modes of cancer cell invasion and metastasis, to distinguish this class from conventional cytostatic drugs, which are mainly directed against cell proliferation. We define actin polymerization and contractility as target mechanisms for migrastatics, and review candidate migrastatic drugs. Critical assessment of these antimetastatic agents is warranted, because they may define new options for the treatment of solid cancers.

引用

页码：391 / 406

页数：16

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