Hyperpolarized Xe NMR signal advancement by metal-organic framework entrapment in solution

被引：187

作者：

Zeng, Qingbin ^{[1
]}

Bie, Binglin ^{[2
]}

Guo, Qianni ^{[1
,3
]}

Yuan, Yaping ^{[1
,3
]}

Han, Qi ^{[2
]}

Han, Xiaocang ^{[4
]}

Chen, Mingwei ^{[4
]}

Zhang, Xu ^{[1
,3
]}

Yang, Yunhuang ^{[1
,3
]}

Liu, Maili ^{[1
,3
]}

Liu, Pan ^{[4
]}

Deng, Hexiang ^{[2
,5
]}

Zhou, Xin ^{[1
,3
]}

机构：

[1] Chinese Acad Sci, Innovat Acad Precis Measurement Sci & Technol, Wuhan Natl Lab Optoelect,Natl Ctr Magnet Resonanc, Wuhan Inst Phys & Math,Natl Ctr Magnet Resonance, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Coll Chem & Mol Sci, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

[4] Shanghai Jiao Tong Univ, Sch Mat Sci & Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China

[5] Wuhan Univ, Inst Adv Studies, Wuhan 430072, Peoples R China

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2020年 / 117卷 / 30期

基金：

中国博士后科学基金; 国家重点研发计划; 中国国家自然科学基金;

关键词：

MOFs; NMR; Hyper-CEST; MRI; signal advancement; NUCLEAR-MAGNETIC-RESONANCE; XE-129; NMR; FUNCTIONAL-GROUPS; XENON; MRI; CRYPTOPHANE; VENTILATION; SERIES;

D O I：

10.1073/pnas.2004121117

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We report hyperpolarized Xe signal advancement by metal-organic framework (MOF) entrapment (Hyper-SAME) in aqueous solution. The Xe-129 NMR signal is drastically promoted by entrapping the Xe into the pores of MOFs. The chemical shift of entrapped Xe-129 is clearly distinguishable from that of free Xe-129 in water, due to the surface and pore environment of MOFs. The influences from the crystal size of MOFs and their concentration in water are studied. A zinc imidazole MOF, zeolitic imidazole framework-8 (ZIF-8), with particle size of 110 nm at a concentration of 100 mg/mL, was used to give an NMR signal with intensity four times that of free Xe-129 in water. Additionally, Hyper-SAME is compatible with hyperpolarized Xe-129 chemical exchange saturation transfer. The Xe-129 NMR signal can be amplified further by combining the two techniques. More importantly, Hyper-SAME provides a way to make detection of hyperpolarized Xe-129 in aqueous solution convenient and broadens the application area of MOFs.

引用

页码：17558 / 17563

页数：6

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