Melanoma and nonmelanoma skin cancer chemoprevention: Arole for nicotinamide?

被引：20
作者：
Minocha, Rashi [1 ,2 ]
Damian, Diona L. [1 ,2 ,3 ]
Halliday, Gary M. [1 ,2 ]
机构：
[1] Univ Sydney, Bosch Inst, Cent Clin Sch, Discipline Dermatol, Sydney, NSW, Australia
[2] Royal Prince Alfred Hosp, Dermatol Sydney Canc Ctr, Sydney, NSW, Australia
[3] Melanoma Inst Australia, Sydney, NSW, Australia
来源：
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE | 2018年 / 34卷 / 01期
关键词：
niacinamide; nicotinamide; skin cancer; RADIATION-INDUCED IMMUNOSUPPRESSION; CUTANEOUS MALIGNANT-MELANOMA; DNA-DAMAGE; HUMAN KERATINOCYTES; INDUCED SUPPRESSION; SUN PROTECTION; RETINOIC ACID; UV-RADIATION; DOUBLE-BLIND; GREEN TEA;
D O I：
10.1111/phpp.12328
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8-oxo-7-hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR, propagate carcinogenesis. Nicotinamide (Vitamin B-3) enhances DNA repair, modulates the inflammatory environment produced by UVR, and reduces UV-induced immunosuppression. As nicotinamide reduces the incidence of actinic keratoses and nonmelanoma skin cancers in high-risk individuals and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations.
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收藏
页码：5 / 12
页数：8
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