Sudden death and myocardial infarction in first degree relatives as predictors of primary cardiac arrest

被引:67
作者
Friedlander, Y
Siscovick, DS
Arbogast, P
Psaty, BM
Weinmann, S
Lemaitre, RN
Raghunathan, TE
Cobb, LA
机构
[1] Hebrew Univ Jerusalem, Hadassah Sch Pub Hlth, Dept Social Med, IL-91120 Jerusalem, Israel
[2] Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA
[3] Univ Washington, Dept Epidemiol, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA
[4] Univ Michigan, Inst Social Res, Ann Arbor, MI USA
关键词
sudden death; myocardial infarction; family history; risk factors;
D O I
10.1016/S0021-9150(01)00701-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The hypothesis that family history (FH) of myocardial infarction (MI) and FH of sudden death (SD) are both independent risk factors for primary cardiac arrest (PCA) was examined in a case-control study. PCA cases were attended by paramedics (1988-1994) and community-based age and sex matched controls were identified. Subjects (125-74 years) were free of prior clinically-recognized heart disease and major co-morbidity. Interviewers obtained a detailed history of MI and SD in first-degree relatives from Spouses of 235 cases and 374 control subjects. A parental history of early-onset SD (age < 65) was associated with an increased risk of PCA (odds ratio (OR) = 2.69, 95%, CI = 1.35-5.36), after adjustment for parental history of MI and other risk factors. A parental history of late-onset SD was not associated with PCA risk (OR = 0.94, 95% CI = 0.55-1.62). Additionally, parental history of SD was related to early-onset PCA (OR = 1.89 95%, CI = 1.08-3.30) but not to late-onset PCA (OR = 0.89, 95% CI = 0.49-1.61). In contrast, parental MI (early/late) was related to PCA (early late), after adjustment for other risk factors and parental history of SD. Similar results were observed in first-degree relatives. Findings suggest a potential role of familial factors related to both MI and SD in PCA. Stronger findings for a familial patterning of PCA were noted for early onset disease in cases and their relatives. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:211 / 216
页数:6
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