Resting spontaneous activity in the default mode network predicts performance decline during prolonged attention workload

被引:52
作者
Gui, Danyang [1 ,7 ]
Xu, Sihua [2 ,4 ]
Zhu, Senhua [1 ,4 ]
Fang, Zhuo [1 ,4 ]
Spaeth, Andrea M. [1 ,5 ]
Xin, Yuanyuan [6 ]
Feng, Tingyong [6 ]
Rao, Hengyi [1 ,3 ,4 ]
机构
[1] Univ Penn, Ctr Funct Neuroimaging, Dept Neurol, Philadelphia, PA 19104 USA
[2] Guangdong Univ Finance & Econ, Dept Appl Psychol, Guangzhou, Guangdong, Peoples R China
[3] Shanghai Int Studies Univ, Coll Int Business, Lab Appl Brain & Cognit Sci, Shanghai, Peoples R China
[4] Sun Yat Sen Univ, Dept Psychol, Guangzhou 510275, Guangdong, Peoples R China
[5] Univ Penn, Ctr Sleep & Circadian Neurobiol, Philadelphia, PA 19104 USA
[6] Southwest Univ, Sch Psychol, Chongqing, Peoples R China
[7] Beijing Normal Univ, Natl Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
Time-on-task (TOT) effects; Fatigue; Default mode network (DMN); Amplitudes of low-frequency fluctuation (ALFF); Functional connectivity; TIME-ON-TASK; LOW-FREQUENCY FLUCTUATION; SLEEP-DEPRIVATION; BRAIN ACTIVITY; WORKING-MEMORY; STATE FMRI; FATIGUE; AMPLITUDE; VIGILANCE; DISEASE;
D O I
10.1016/j.neuroimage.2015.07.030
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
After continuous and prolonged cognitive workload, people typically show reduced behavioral performance and increased feelings of fatigue, which are known as "time-on-task (TOT) effects". Although TOT effects are pervasive in modern life, their underlying neural mechanisms remain elusive. In this study, we induced TOT effects by administering a 20-min continuous psychomotor vigilance test (PVT) to a group of 16 healthy adults and used resting-state blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) to examine spontaneous brain activity changes associated with fatigue and performance. Behaviorally, subjects displayed robust TOT effects, as reflected by increasingly slower reaction times as the test progressed and higher self-reported mental fatigue ratings after the 20-min PVT. Compared to pre-test measurements, subjects exhibited reduced amplitudes of low-frequency fluctuation (ALFF) in the default mode network (DMN) and increased ALFF in the thalamus after the test. Subjects also exhibited reduced anti-correlations between the posterior cingulate cortex (PCC) and right middle prefrontal cortex after the test. Moreover, pre-test resting ALFF in the PCC and medial prefrontal cortex (MePFC) predicted subjects' subsequent performance decline; individuals with higher ALFF in these regions exhibited more stable reaction times throughout the 20-min PVT. These results support the important role of both task-positive and task-negative networks in mediating TOT effects and suggest that spontaneous activity measured by resting-state BOLD fMRI may be a marker of mental fatigue. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:323 / 330
页数:8
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