Resting-State Oscillatory Dynamics in Sensorimotor Cortex in Benign Epilepsy With Centro-Temporal Spikes and Typical Brain Development

被引:29
作者
Koelewijn, Loes [1 ]
Hamandi, Khalid [1 ]
Brindley, Lisa M. [1 ]
Brookes, Matthew J. [2 ]
Routley, Bethany C. [1 ]
Muthukumaraswamy, Suresh D. [3 ,4 ]
Williams, Natalie [5 ]
Thomas, Marie A. [5 ]
Kirby, Amanda [5 ]
Naude, Johann te Water [6 ]
Gibbon, Frances [6 ]
Singh, Krish D. [1 ]
机构
[1] Cardiff Univ, Sch Psychol, CUBRIC, Cardiff CF10 3AT, S Glam, Wales
[2] Univ Nottingham, Sch Phys & Astron, Sir Peter Mansfield Magnet Resonance Ctr, Nottingham NG7 2RD, England
[3] Univ Auckland, Sch Pharm, Auckland 1, New Zealand
[4] Univ Auckland, Sch Psychol, Auckland 1, New Zealand
[5] Univ South Wales, Dyscovery Ctr, Newport, Shrops, England
[6] Univ Wales Hosp, Child Hlth, Cardiff CF4 4XW, S Glam, Wales
关键词
benign epilepsy with centro-temporal spikes; resting-state networks; magnetoencephalography; sensorimotor cortex; beta-band oscillations; INDEPENDENT COMPONENT ANALYSIS; HIGH-FREQUENCY OSCILLATIONS; EEG BACKGROUND ACTIVITY; PRIMARY MOTOR CORTEX; ROLANDIC EPILEPSY; FUNCTIONAL CONNECTIVITY; CENTROTEMPORAL SPIKES; GAMMA-OSCILLATIONS; CHILDHOOD EPILEPSY; INTERICTAL SPIKES;
D O I
10.1002/hbm.22888
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Benign Epilepsy with Centro-Temporal Spikes (BECTS) is a common childhood epilepsy associated with deficits in several neurocognitive domains. Neurophysiological studies in BECTS often focus on centro-temporal spikes, but these correlate poorly with morphology and cognitive impairments. To better understand the neural profile of BECTS, we studied background brain oscillations, thought to be integrally involved in neural network communication, in sensorimotor areas. We used independent component analysis of temporally correlated sources on magnetoencephalography recordings to assess sensorimotor resting-state network activity in BECTS patients and typically developing controls. We also investigated the variability of oscillatory characteristics within focal primary motor cortex (M1), localized with a separate finger abduction task. We hypothesized that background oscillations would differ between patients and controls in the sensorimotor network but not elsewhere, especially in the beta band (13-30 Hz) because of its role in network communication and motor processing. The results support our hypothesis: in the sensorimotor network, patients had a greater variability in oscillatory amplitude compared to controls, whereas there was no difference in the visual network. Network measures did not correlate with age. The coefficient of variation of resting M1 peak frequency correlated negatively with age in the beta band only, and was greater than average for a number of patients. Our results point toward a "disorganized" functional sensorimotor network in BECTS, supporting a neurodevelopmental delay in sensorimotor cortex. Our findings further suggest that investigating the variability of oscillatory peak frequency may be a useful tool to investigate deficits of disorganization in neurodevelopmental disorders. (C) 2015 Wiley Periodicals, Inc.
引用
收藏
页码:3935 / 3949
页数:15
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