Low immature platelet fraction suggests decreased megakaryopoiesis in neonates with sepsis or necrotizing enterocolitis

被引：32

作者：

Cremer, M. ^{[1
]}

Weimann, A. ^{[2
,3
]}

Szekessy, D. ^{[1
]}

Hammer, H. ^{[1
]}

Buehrer, C. ^{[1
]}

Dame, C. ^{[1
]}

机构：

[1] Charite, Dept Neonatol, D-10117 Berlin, Germany

[2] Charite, Inst Lab Med & Pathobiochem, D-10117 Berlin, Germany

[3] Lab Berlin Charity Vivantes, Berlin, Germany

来源：

JOURNAL OF PERINATOLOGY | 2013年 / 33卷 / 08期

关键词：

thrombocytopenia; platelet transfusion; mean platelet volume; nucleated red blood cells; erythroblast; RED-BLOOD-CELLS; BACTERIAL-INFECTION; THROMBOCYTOPENIA; THROMBOPOIETIN; INSIGHTS; VOLUME; COUNT;

D O I：

10.1038/jp.2013.21

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: In order to conclude on the megakaryopoietic activity during thrombocytopenia in sepsis or necrotizing enterocolitis (NEC), we analyzed the immature platelet fraction (IPF). STUDY DESIGN: Serial measurements of platelet counts and IPF in neonates with blood culture-proven late-onset sepsis (n = 21) or surgical NEC (n 12) at T0: prior to the diagnosis of sepsis/NEC; T1: at diagnosis; T2: days 3 to 5 after onset; T3: days 8 to 12 after onset. RESULT: In parallel to declining platelet counts, the median absolute IPF significantly decreased between T0 and T2 in neonates with sepsis or NEC. We found a significant positive correlation between the platelet count and absolute IPF (r = 0.71; P<0.001). In patients with low IPF (<2 per nl), the platelet count did not subsequently increase. Neonates with NEC who died exhibited significantly lower IPF compared with survivors (P<0.05). CONCLUSION: Low absolute IPF values during the course of neonatal sepsis/NEC suggest suppression of megakaryopoietic activity.

引用

页码：622 / 626

页数：5

共 30 条

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