Polymeric micelles for pulmonary drug delivery: a comprehensive review

被引：67

作者：

Pham, Duy Toan ^{[1
,2
]}

Chokamonsirikun, Athittaya ^{[2
]}

Phattaravorakarn, Vipasiri ^{[2
]}

Tiyaboonchai, Waree ^{[2
,3
,4
]}

机构：

[1] Can Tho Univ, Dept Chem, Coll Nat Sci, Can Tho 900000, Vietnam

[2] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol, 99 Moo 9, Phitsanulok 65000, Thailand

[3] Mahidol Univ, Dept Chem, Salaya 73170, Nakhon Pathom, Thailand

[4] Mahidol Univ, Ctr Excellence Innovat Chem, Fac Sci, Ctr Excellence Innovat Chem PERCH CIC, Salaya 73170, Nakhon Pathom, Thailand

来源：

JOURNAL OF MATERIALS SCIENCE | 2021年 / 56卷 / 03期

关键词：

BLOCK-COPOLYMER MICELLES; IN-VITRO; DIBLOCK COPOLYMERS; AMPHOTERICIN-B; MIXED MICELLES; DRY POWDERS; NANOPARTICLES; NANOCARRIERS; PARTICLES; RELEASE;

D O I：

10.1007/s10853-020-05361-4

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Respiratory diseases have remained one of the most common diseases worldwide, in which oral and intravenous administration are the most common treatment routes. However, these administrative routes face various difficulties in reaching local pulmonary targets, possessing low efficacy, and have high risk of systemic side effects. To solve these issues, polymeric micelles represent an effective approach. These nano-ranged delivery systems can encapsulate and protect poorly water-soluble drugs, enhance drug targeting to the lung, reduce side effects, and improve drug efficacy via inhalation route. In this review, the importance of rational design was highlighted by summarizing the recent progress on the development of polymeric micelles in pulmonary delivery. Emphasis is also placed on the different types and preparations, as well as ideal properties and advantages of polymeric micelles for pulmonary route. Graphic abstract

引用

页码：2016 / 2036

页数：21

共 142 条

[1] Curcumin loaded polymeric micelles of variable hydrophobic lengths by RAFT polymerization: Preparation and in-vitro characterization [J].