Comparison of 2 Diagnostic Criteria for the Behavioral Variant of Frontotemporal Dementia

被引：10

作者：

Costa, Sonia ^{[1
,2
]}

Suarez-Calvet, Marc ^{[1
]}

Anton, Sofia ^{[1
]}

Dols-Icardo, Oriol ^{[1
]}

Clarimon, Jordi ^{[1
]}

Alcolea, Daniel ^{[1
]}

Fortea, Juan ^{[1
]}

Carmona, Maria ^{[1
]}

Sala, Isabel ^{[1
]}

Belen Sanchez-Saudinos, M. ^{[1
]}

Blesa, Rafael ^{[1
]}

Lleo, Alberto ^{[1
]}

机构：

[1] Univ Autonoma Barcelona, Dept Neurol, Memory Disorders Unit, Hosp Santa Creu & St Pau,IIB St Pau, E-08193 Barcelona, Spain

[2] Hosp Prof Dr Fernando Fonseca, Dept Neurol, Amadora, Portugal

来源：

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS | 2013年 / 28卷 / 05期

关键词：

behavioral variant frontotemporal dementia; frontotemporal lobar degeneration; frontotemporal dementia; diagnostic criteria; C9orf72; differential diagnosis; diagnosis of neurodegenerative diseases; HEXANUCLEOTIDE REPEAT EXPANSION; PROGRESSIVE SUPRANUCLEAR PALSY; LOBAR DEGENERATION; CORTICOBASAL DEGENERATION; ALZHEIMERS-DISEASE; EARLY-ONSET; C9ORF72; ACCURACY; SENSITIVITY; ALCOHOLISM;

D O I：

10.1177/1533317513488918

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objectives The aim of this study was to compare the applicability of the 1998 consensus diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD) with the recently proposed diagnostic criteria of the International bvFTD Criteria Consortium (FTDC). Methods We reviewed each individual item in the 1998 and FTDC criteria in 30 patients with bvFTD followed in a memory clinic (including 2 with the C9orf72 gene repeat expansion). Results All patients fulfilled the FTDC criteria (40% possible, 60% probable bvFTD) but only 66.7% fulfilled the 1998 criteria. One of the C9orf72 expansion carriers did not fulfill the 1998 criteria. This discordance was always due to the presence of exclusion features in the 1998 criteria, the most common being spatial disorientation and early severe amnesia. Conclusion The new FTDC criteria are less restrictive and hence more sensitive for the diagnosis of bvFTD.

引用

页码：469 / 476

页数：8

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