Resveratrol Improves Adipose Insulin Signaling and Reduces the Inflammatory Response in Adipose Tissue of Rhesus Monkeys on High-Fat, High-Sugar Diet

被引：199

作者：

Jimenez-Gomez, Yolanda ^{[1
]}

Mattison, Julie A. ^{[1
]}

Pearson, Kevin J. ^{[1
,3
]}

Martin-Montalvo, Alejandro ^{[1
]}

Palacios, Hector H. ^{[1
]}

Sossong, Alex M. ^{[1
]}

Ward, Theresa M. ^{[1
]}

Younts, Caitlin M. ^{[1
]}

Lewis, Kaitlyn ^{[1
]}

Allard, Joanne S. ^{[1
,4
]}

Longo, Dan L. ^{[5
]}

Belman, Jonathan P. ^{[6
,7
]}

Malagon, Maria M. ^{[8
,9
]}

Navas, Placido ^{[10
,11
]}

Sanghvi, Mitesh ^{[2
]}

Moaddel, Ruin ^{[2
]}

Tilmont, Edward M. ^{[1
]}

Herbert, Richard L. ^{[12
]}

Morrell, Christopher H. ^{[13
]}

Egan, Josephine M. ^{[2
]}

Baur, Joseph A. ^{[14
]}

Ferrucci, Luigi ^{[15
]}

Bogan, Jonathan S. ^{[6
,7
]}

Bernier, Michel ^{[1
]}

de Cabo, Rafael ^{[1
]}

机构：

[1] NIA, Translat Gerontol Branch, Intramural Res Program, NIH, Baltimore, MD 21224 USA

[2] NIA, Lab Clin Invest, NIH, Baltimore, MD 21224 USA

[3] Univ Kentucky, Grad Ctr Nutr Sci, Lexington, KY 40536 USA

[4] Howard Univ Coll Med, Dept Physiol & Biophys, Washington, DC 20059 USA

[5] NIA, Lab Mol Biol & Immunol, NIH, Baltimore, MD 21224 USA

[6] Yale Univ Sch Med, Dept Internal Med, Sect Endocrinol, New Haven, CT 06520 USA

[7] Yale Univ Sch Med, Dept Cell Biol, New Haven, CT 06520 USA

[8] Univ Cordoba, Dept Cell Biol Physiol & Immunol, IMIBIC, Reina Sofia Univ Hosp, Cordoba 14014, Spain

[9] CIBERobn, Cordoba 14014, Spain

[10] Univ Pablo Olavide CSIC, Inst Salud Carlos III, Ctr Andaluz Biol Desarrollo, Seville 41013, Spain

[11] Univ Pablo Olavide CSIC, Inst Salud Carlos III, CIBERER, Seville 41013, Spain

[12] NIAID, Clin Med Branch, NIH, Poolesvile, MD 20837 USA

[13] Loyola Univ Maryland, Dept Math & Stat, Baltimore, MD 21210 USA

[14] Univ Penn, Inst Diabet Obes & Metab, Sch Med, Dept Physiol, Philadelphia, PA 19104 USA

[15] NIA, Longitudinal Studies Sect, Clin Res Branch, NIH, Baltimore, MD 21225 USA

来源：

CELL METABOLISM | 2013年 / 18卷 / 04期

关键词：

NECROSIS-FACTOR-ALPHA; GENE-EXPRESSION; SIRT1; RESISTANCE; ADIPOCYTES; ACTIVATION; BETA; SUPPLEMENTATION; TRANSCRIPTION; MACROPHAGES;

D O I：

10.1016/j.cmet.2013.09.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity is associated with a chronic, low-grade, systemic inflammation that may contribute to the development of insulin resistance and type 2 diabetes. Resveratrol, a natural compound with anti-inflammatory properties, is shown to improve glucose tolerance and insulin sensitivity in obese mice and humans. Here, we tested the effect of a 2-year resveratrol administration on proinflammatory profile and insulin resistance caused by a high-fat, high-sugar (HFS) diet in white adipose tissue (WAT) from rhesus monkeys. Resveratrol supplementation (80 and 480 mg/day for the first and second year, respectively) decreased adipocyte size, increased sirtuin 1 expression, decreased NF-kappa B activation, and improved insulin sensitivity in visceral, but not subcutaneous, WAT from HFS-fed animals. These effects were reproduced in 3T3-L1 adipocytes cultured in media supplemented with serum from monkeys fed HFS +/- resveratrol diets. In conclusion, chronic administration of resveratrol exerts beneficial metabolic and inflammatory adaptations in visceral WAT from diet-induced obese monkeys.

引用

页码：533 / 545

页数：13

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