Molecular epidemiology and characterization of human coronavirus in Thailand, 2012-2013

被引：8
作者：
Soonnarong, Rapeepun [2 ]
Thongpan, Ilada [1 ]
Payungporn, Sunchai [2 ]
Vuthitanachot, Chanpim [3 ]
Vuthitanachot, Viboonsuk [3 ]
Vichiwattana, Preeyaporn [1 ]
Vongpunsawad, Sompong [1 ]
Poovorawan, Yong [1 ,2 ]
机构：
[1] Chulalongkorn Univ, Fac Med, Ctr Excellence Clin Virol, Dept Pediat, Bangkok, Thailand
[2] Chulalongkorn Univ, Fac Med, Dept Biochem, Bangkok, Thailand
[3] Chum Phae Hosp, Khon Kaen, Thailand
来源：
SPRINGERPLUS | 2016年 / 5卷
关键词：
Human coronavirus (HCoV); Epidemiology; Respiratory tract infection (RTI); Thailand; RESPIRATORY-TRACT INFECTIONS; POLYMERASE-CHAIN-REACTION; FREQUENT DETECTION; CHILDREN; TIME; ILLNESS; ADULTS; NL63; PREVALENCE; INFLUENZA;
D O I：
10.1186/s40064-016-3101-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: Coronavirus causes respiratory infections in humans. To determine the prevalence of human coronavirus (HCoV) infection among patients with influenza-like illness, 5833 clinical samples from nasopharyngeal swabs and aspirates collected between January 2012 and December 2013 were examined. Results: HCoV was found in 46 (0.79 %) samples. There were 19 (0.32 %) HCoV-HKU1, 19 (0.32 %) HCoV-NL63, 5 (0.09 %) HCoV-229E, and 3 (0.05 %) HCoV-OC43. None of the sample tested positive for MERS-CoV. The majority (54 %) of the HCoV-positive patients were between the ages of 0 and 5 years. HCoV was detected throughout the 2-year period and generally peaked from May to October, which coincided with the rainy season. Phylogenetic trees based on the alignment of the spike (S) gene sequences suggest an emergence of a new clade for HCoV-229E. Conclusions: The data in this study provide an insight into the prevalence of the recent circulating HCoVs in the region.
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页数：8
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