Acyclic Cucurbit[n]uril-Type Molecular Containers Bind Neuromuscular Blocking Agents In Vitro and Reverse Neuromuscular Block In Vivo

被引：134
作者：
Ma, Da [1 ]
Zhang, Ben [1 ]
Hoffmann, Ulrike [2 ,3 ,4 ]
Sundrup, Martina Grosse [2 ,3 ]
Eikermann, Matthias [2 ,3 ,5 ]
Isaacs, Lyle [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[2] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Tech Univ Munich, Klin Anaesthesiol, Klinikum Rechts Isar, D-81675 Munich, Germany
[5] Essen Duisburg Univ, Dept Anesthesia & Intens Care Med, Duisburg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 45期
基金：
美国国家科学基金会;
关键词：
cucurbit[n]uril; host-guest systems; medicinal chemistry; molecular recognition; neuromuscular blocking agents; MUSCLE-ACTIVITY; SUGAMMADEX; RECOGNITION; SELECTIVITY; COMPLEXES; AFFINITY; ENHANCE;
D O I：
10.1002/anie.201206031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO 3--groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11358 / 11362
页数：5
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