Acyclic Cucurbit[n]uril-Type Molecular Containers Bind Neuromuscular Blocking Agents In Vitro and Reverse Neuromuscular Block In Vivo

被引：134
作者：
Ma, Da [1 ]
Zhang, Ben [1 ]
Hoffmann, Ulrike [2 ,3 ,4 ]
Sundrup, Martina Grosse [2 ,3 ]
Eikermann, Matthias [2 ,3 ,5 ]
Isaacs, Lyle [1 ]
机构：
[1] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20742 USA
[2] Massachusetts Gen Hosp, Dept Anesthesia Crit Care & Pain Med, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Tech Univ Munich, Klin Anaesthesiol, Klinikum Rechts Isar, D-81675 Munich, Germany
[5] Essen Duisburg Univ, Dept Anesthesia & Intens Care Med, Duisburg, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 45期
基金：
美国国家科学基金会;
关键词：
cucurbit[n]uril; host-guest systems; medicinal chemistry; molecular recognition; neuromuscular blocking agents; MUSCLE-ACTIVITY; SUGAMMADEX; RECOGNITION; SELECTIVITY; COMPLEXES; AFFINITY; ENHANCE;
D O I：
10.1002/anie.201206031
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Be My Guest: Two acyclic cucurbit[n]uril-type receptors that carry SO 3--groups bind tightly to several commonly used neuromuscular blocking agents, such as rocuronium, in aqueous solution as revealed by direct and competitive UV/Vis binding assays. One of these containers functions as a potent reversal agent for rocuronium-induced neuromuscular block in rats. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：11358 / 11362
页数：5
相关论文
共 48 条
  • [1] Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide: Synthesis and structure-activity relationships
    Adam, JM
    Bennett, DJ
    Bom, A
    Clark, JK
    Feilden, H
    Hutchinson, EJ
    Palin, R
    Prosser, A
    Rees, DC
    Rosair, GM
    Stevenson, D
    Tarver, GJ
    Zhang, MQ
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (09) : 1806 - 1816
  • [2] pH Clock-Operated Mechanized Nanoparticles
    Angelos, Sarah
    Khashab, Niveen M.
    Yang, Ying-Wei
    Trabolsi, Ali
    Khatib, Hussam A.
    Stoddart, J. Fraser
    Zink, Jeffrey I.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (36) : 12912 - +
  • [3] [Anonymous], 2005, ANGEW CHEM, DOI DOI 10.1002/ANIE.201210267
  • [4] Supramolecular analytical chemistry
    Anslyn, Eric V.
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2007, 72 (03) : 687 - 699
  • [5] Supramolecular Cross-Linked Networks via Host-Guest Complexation with Cucurbit[8]uril
    Appel, Eric A.
    Biedermann, Frank
    Rauwald, Urs
    Jones, Samuel T.
    Zayed, Jameel M.
    Scherman, Oren A.
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 132 (40) : 14251 - 14260
  • [6] Residual neuromuscular block is a risk factor for postoperative pulmonary complications - A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium
    Berg, H
    VibyMogensen, J
    Roed, J
    Mortensen, CR
    Engbaek, J
    Skovgaard, LT
    Krintel, JJ
    [J]. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1997, 41 (09) : 1095 - 1103
  • [7] REVERSAL OF NEUROMUSCULAR BLOCKADE
    BEVAN, DR
    DONATI, F
    KOPMAN, AF
    [J]. ANESTHESIOLOGY, 1992, 77 (04) : 785 - 805
  • [8] Benzobis(imidazolium)-Cucurbit[8]uril Complexes for Binding and Sensing Aromatic Compounds in Aqueous Solution
    Biedermann, Frank
    Rauwald, Urs
    Cziferszky, Monika
    Williams, Kyle A.
    Gann, Lauren D.
    Guo, Bi Y.
    Urbach, Adam R.
    Bielawski, Christopher W.
    Scherman, Oren A.
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (46) : 13716 - 13722
  • [9] Bom A, 2002, ANGEW CHEM INT EDIT, V41, P266
  • [10] Modified γ-cyclodextrins and their rocuronium complexes
    Cameron, KS
    Clark, JK
    Cooper, A
    Fielding, L
    Palin, R
    Rutherford, SJ
    Zhang, MQ
    [J]. ORGANIC LETTERS, 2002, 4 (20) : 3403 - 3406
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