STABILITY INDICATING METHOD FOR SIMULTANEOUS DETERMINATION OF PARACETAMOL AND ACECLOFENAC USING ATR-FTIR ASSISTED BY CHEMOMETRICS

An attenuated total reflectance-fourier transform infrared (ATR-FTIR) spectroscopy method was developed for the simultaneous estimation of paracetamol and aceclofenac in Pharmaceutical tablets. The method involves the direct determination in the drug through peak measurement in the 3502 cm-1 for paracetamol and 1436 cm(-1) for aceclofenac using a baseline correction between 3800 and 1000 cm(-1). For standardization an external calibration line established from standard solutions of pure paracetamol and aceclofenac were used. The method provides a limit of detection for paracetamol is 9.18 and for aceclofenac is 7.95 for per mg tablet and Limit of Quantification for paracetamol is 27.84 and for aceclofenac is 24.11583 for per mg tablet. The accuracy of the sample was found to be 0.816% for paracetamol and 1.32% for aceclofenac. A relative standard deviation (RSD) for 3 independent measurement of standard and test solution at a concentration level of 1.5 mg/mL for paracetamol and aceclofenac is 0.000577%. Range for the tablet was 10 mu g/mL to 250 mu g/mL for paracetamol and 10 mu g/mL to 300 mu g/mL for aceclofenac. The assay of the marketed tablet was found to be 149% and 142% for aceclofenac and paracetamol, the purity of the tablet was 65%. Result obtained by FTIR shows the developed procedure and offers a good alternative for the simultaneous determination of paracetamol and aceclofenac in commercialproducts.