Synthesis of 2(1H)-Quinolinones via Pd-Catalyzed Oxidative Cyclocarbonylation of 2-Vinylanilines

被引：103

作者：

Ferguson, Jamie ^{[1
]}

Zeng, Fanlong ^{[1
]}

Alwis, Natacha ^{[1
]}

Alper, Howard ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 08期

基金：

加拿大自然科学与工程研究理事会;

关键词：

CARBONYLATIVE ANNULATION; DERIVATIVES; CYCLIZATION; AMIDATION; COUMARINS; ACTIVATION; COMPLEXES; LACTAMS; ALKYNES; ROUTES;

D O I：

10.1021/ol4006739

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-catalyzed oxidative cyclocarbonylation of N-monosubstituted-2-vinylanilines constitutes a simple, direct, and selective method for the synthesis of 2(1H)-quinolinones. The reaction conditions are attractive in terms of environmental considerations and operational simplicity. 2(1H)-Quinolinones with a variety of functional groups were prepared in up to 97% yield.

引用

页码：1998 / 2001

页数：4

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