Non-redundant compendium of human ncRNA genes in GeneCards

被引：33

作者：

Belinky, Frida ^{[1
]}

Bahir, Iris ^{[1
]}

Stelzer, Gil ^{[1
]}

Zimmerman, Shahar ^{[1
]}

Rosen, Naomi ^{[1
]}

Nativ, Noam ^{[1
]}

Dalah, Irina ^{[1
]}

Stein, Tsippi Iny ^{[1
]}

Rappaport, Noa ^{[1
]}

Mituyama, Toutai ^{[2
]}

Safran, Marilyn ^{[1
,3
]}

Lancet, Doron ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

[2] Adv Ind Sci & Technol AIST, Computat Biol Res Ctr CBRC, Koto Ku, Tokyo 1350064, Japan

[3] Weizmann Inst Sci, Dept Biol Serv, IL-76100 Rehovot, Israel

来源：

BIOINFORMATICS | 2013年 / 29卷 / 02期

关键词：

TRANSCRIPTIONAL NOISE; NONCODING RNAS; HUMAN GENOME; DATABASE; ANNOTATION; PIRNA; RESOURCES; SEQUENCES; REGIONS;

D O I：

10.1093/bioinformatics/bts676

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Non-coding RNA (ncRNA) genes are increasingly acknowledged for their importance in the human genome. However, there is no comprehensive non-redundant database for all such human genes. Results: We leveraged the effective platform of GeneCards, the human gene compendium, together with the power of fRNAdb and additional primary sources, to judiciously unify all ncRNA gene entries obtainable from 15 different primary sources. Overlapping entries were clustered to unified locations based on an algorithm employing genomic coordinates. This allowed GeneCards' gamut of relevant entries to rise similar to 5-fold, resulting in similar to 80 000 human non-redundant ncRNAs, belonging to 14 classes. Such 'grand unification' within a regularly updated data structure will assist future ncRNA research.

引用

页码：255 / 261

页数：7

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