Subclinical epileptiform activity in children with electrical status epilepticus during sleep: Effects on cognition and behavior before and after treatment with levetiracetam

被引：21

作者：

Bjornaes, Helge ^{[1
]}

Bakke, Kristin A. ^{[1
]}

Larsson, Pal Gunnar ^{[2
]}

Heminghyt, Einar ^{[1
]}

Rytter, Elisif ^{[1
]}

Brager-Larsen, Line M. ^{[3
]}

Eriksson, Ann-Sofie ^{[1
]}

机构：

[1] Oslo Univ Hosp, Natl Ctr Epilepsy, Oslo, Norway

[2] Oslo Univ Hosp, Dept Neurosurg, Oslo, Norway

[3] Vestre Viken Hosp Thrust, Drammen, Norway

来源：

EPILEPSY & BEHAVIOR | 2013年 / 27卷 / 01期

关键词：

Electrical Status Epilepticus during Sleep (ESES); EEG; Levetiracetam; Learning and memory; Vigilance; Behavior; Spike index; BENIGN CHILDHOOD EPILEPSY; LANDAU-KLEFFNER-SYNDROME; EEG ABNORMALITIES; DIFFICULTIES QUESTIONNAIRE; FORCED NORMALIZATION; ENCEPHALOPATHY; DISCHARGES; SPECTRUM; DEFICIT; PERFORMANCE;

D O I：

10.1016/j.yebeh.2012.12.007

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We performed a double-blind placebo-controlled crossover study of the effects of spike activity during sleep and when awake on learning, long-term memory, vigilance and behavior before and after treatment with levetiracetam in children with electrical status epilepticus during sleep. At baseline, verbal learning declined with increasing spike activity, but there were no relations between spike activity and memory, vigilance or behavior. Levetiracetam was effective in reducing sleep-related spike activity, but on a group level, this had no clear effects on behavior, vigilance or learning and memory. Our results do not allow firm conclusions whether to treat nocturnal epileptiform activity or not; larger samples and longer follow-up may be needed. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：40 / 48

页数：9

共 64 条

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