Where There's Smoke, There's Fire: Inflammation Drives MDS

被引：5

作者：

Datar, Gandhar K. ^{[1
,2
,3
]}

Goodell, Margaret A. ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Canc & Cell Biol Grad Program, Houston, TX 77008 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Ctr Cell & Gene Therapy, Houston, TX 77008 USA

[3] Baylor Coll Med, Stem Cells & Regenerat Med Ctr, Houston, TX 77008 USA

来源：

TRENDS IN IMMUNOLOGY | 2020年 / 41卷 / 07期

基金：

美国国家卫生研究院;

关键词：

GENE; CONTRIBUTES; APOPTOSIS; CELLS;

D O I：

10.1016/j.it.2020.05.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic inflammation has been implicated in myelodysplastic syndrome (MDS); however, its role in disease progression is unclear. In a new study by Muto et al., MDS stem cells sparked with TRAF6-activated innate immune signaling were found to outcompete normal counterparts only when fueled by environmental inflammatory stimuli. Non-canonical NF-kappa B signaling is implicated in inflammatory synergy and MDS progression.

引用

页码：558 / 560

页数：4

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