Isobutylhydroxyamides from the Pericarp of Nepalese Zanthoxylum armatum Inhibit NF1-Defective Tumor Cell Line Growth

被引：62

作者：

Devkota, Krishna P. ^{[1
]}

Wilson, Jennifer ^{[1
]}

Henrich, Curtis J. ^{[1
,2
]}

McMahon, James B. ^{[1
]}

Reilly, Karlyne M. ^{[3
]}

Beutler, John A. ^{[1
]}

机构：

[1] Frederick Natl Lab Canc Res, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA

[2] Frederick Natl Lab Canc Res, SAIC Frederick, Frederick, MD 21702 USA

[3] Frederick Natl Lab Canc Res, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ALIPHATIC ACID-AMIDES; CONSTITUENTS; PIPERITUM; BUNGEANUM; HUAJIAO; AGENTS; NF1;

D O I：

10.1021/np300696g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A neurofibromatosis type 1 (NF1)-based bioassay-guided phytochemical investigation on Zanthoxylum armatum collected in Nepal led to the isolation of new timuramides A-D (1-4) and six known sanshools (5-10). The structures of all compounds were established by using modern spectroscopic techniques, including 1D and 2D NMR analysis and comparison with previously reported data. Most of the compounds inhibited growth of an Nf1- and p53-deficient mouse glioma cell line at noncytotoxic concentrations.

引用

页码：59 / 63

页数：5

共 24 条

[1] Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels [J].

Bautista, Diana M. ;

Sigal, Yaron M. ;

Milstein, Aaron D. ;

Garrison, Jennifer L. ;

Zorn, Julie A. ;

Tsuruda, Pamela R. ;

Nicoll, Roger A. ;

Julius, David .

NATURE NEUROSCIENCE, 2008, 11 (07) :772-779

[2] Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1 [J].

Brems, Hilde ;

Beert, Eline ;

de Ravel, Thomy ;

Legius, Eric .

LANCET ONCOLOGY, 2009, 10 (05) :508-515

[3]

den Hertog WH, 2000, MT RES DEV, V20, P136, DOI 10.1659/0276-4741(2000)020[0136:TZAPIN]2.0.CO

[4]

[5]

DHAR KL, 1967, INDIAN J CHEM, V5, P588

[6] POLYENE ACIDS .6. A NEW (CIS-TRANS-)ISOMER OF SORBIC ACID AND ITS RELATION TO HEXENOLACTONES [J].

EISNER, U ;

ELVIDGE, JA ;

LINSTEAD, RP .

JOURNAL OF THE CHEMICAL SOCIETY, 1953, (MAY) :1372-1379

[7] Determining the absolute stereochemistry of secondary/secondary diols by 1H NMR:: Basis and applications [J].

Freire, F ;

Seco, JM ;

Quiñoá, E ;

Riguera, R .

JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (10) :3778-3790

[8]

Gewali M.B., 2008, Aspects of traditional medicine in Nepal, P140

[9] Aliphatic acid amides of the fruits of Zanthoxylum piperitum [J].

Hatano, T ;

Inada, K ;

Ogawa, T ;

Ito, H ;

Yoshida, T .

PHYTOCHEMISTRY, 2004, 65 (18) :2599-2604

[10] Novel dual-reporter preclinical screen for antiastrocytoma agents identifies cytostatic and cytotoxic compounds [J].

Hawes, Jessica J. ;

Nerva, John D. ;

Reilly, Karlyne M. .

JOURNAL OF BIOMOLECULAR SCREENING, 2008, 13 (08) :795-803

← 1 2 3 →