Isobutylhydroxyamides from the Pericarp of Nepalese Zanthoxylum armatum Inhibit NF1-Defective Tumor Cell Line Growth

被引：61

作者：

Devkota, Krishna P. ^{[1
]}

Wilson, Jennifer ^{[1
]}

Henrich, Curtis J. ^{[1
,2
]}

McMahon, James B. ^{[1
]}

Reilly, Karlyne M. ^{[3
]}

Beutler, John A. ^{[1
]}

机构：

[1] Frederick Natl Lab Canc Res, Ctr Canc Res, Mol Targets Lab, Frederick, MD 21702 USA

[2] Frederick Natl Lab Canc Res, SAIC Frederick, Frederick, MD 21702 USA

[3] Frederick Natl Lab Canc Res, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21702 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ALIPHATIC ACID-AMIDES; CONSTITUENTS; PIPERITUM; BUNGEANUM; HUAJIAO; AGENTS; NF1;

D O I：

10.1021/np300696g

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A neurofibromatosis type 1 (NF1)-based bioassay-guided phytochemical investigation on Zanthoxylum armatum collected in Nepal led to the isolation of new timuramides A-D (1-4) and six known sanshools (5-10). The structures of all compounds were established by using modern spectroscopic techniques, including 1D and 2D NMR analysis and comparison with previously reported data. Most of the compounds inhibited growth of an Nf1- and p53-deficient mouse glioma cell line at noncytotoxic concentrations.

引用

页码：59 / 63

页数：5

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