Transcriptional control of effector and memory CD8+ T cell differentiation

被引：1171

作者：

Kaech, Susan M. ^{[1
,2
]}

Cui, Weiguo ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 11期

基金：

美国国家卫生研究院;

关键词：

CHEMOKINE RECEPTOR CXCR3; CHRONIC VIRAL-INFECTION; CUTTING EDGE; IN-VIVO; TERMINAL DIFFERENTIATION; MITOCHONDRIAL STAT3; PROTECTIVE IMMUNITY; LINEAGE COMMITMENT; CLONAL EXPANSION; VIRUS-INFECTION;

D O I：

10.1038/nri3307

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.

引用

页码：749 / 761

页数：13

共 138 条

[81] JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease [J].

O'Shea, John J. ;

Plenge, Robert .

IMMUNITY, 2012, 36 (04) :542-550

[82] Genomic views of STAT function in CD4+ T helper cell differentiation [J].

O'Shea, John J. ;

Lahesmaa, Riitta ;

Vahedi, Golnaz ;

Laurence, Arian ;

Kanno, Yuka .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (04) :239-250

[83] Pathogen-Induced Inflammatory Environment Controls Effector and Memory CD8+ T Cell Differentiation [J].

Obar, Joshua J. ;

Jellison, Evan R. ;

Sheridan, Brian S. ;

Blair, David A. ;

Quynh-Mai Pham ;

Zickovich, Julianne M. ;

Lefrancois, Leo .

JOURNAL OF IMMUNOLOGY, 2011, 187 (10) :4967-4978

[84] The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns [J].

Oestreich, Kenneth J. ;

Huang, Albert C. ;

Weinmann, Amy S. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 208 (05) :1001-1013

[85] Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function [J].

Palmer, Douglas C. ;

Restifo, Nicholas P. .

TRENDS IN IMMUNOLOGY, 2009, 30 (12) :592-602

[86] Generation of CD8 T cell memory is regulated by IL-12 [J].

Pearce, Erika L. ;

Shen, Hao .

JOURNAL OF IMMUNOLOGY, 2007, 179 (04) :2074-2081

[87] Metabolism in T cell activation and differentiation [J].

Pearce, Erika L. .

CURRENT OPINION IN IMMUNOLOGY, 2010, 22 (03) :314-320

[88] Enhancing CD8 T-cell memory by modulating fatty acid metabolism [J].

Pearce, Erika L. ;

Walsh, Matthew C. ;

Cejas, Pedro J. ;

Harms, Gretchen M. ;

Shen, Hao ;

Wang, Li-San ;

Jones, Russell G. ;

Choi, Yongwon .

NATURE, 2009, 460 (7251) :103-U118

[89] Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells [J].

Pepper, Marion ;

Pagan, Antonio J. ;

Igyarto, Botond Z. ;

Taylor, Justin J. ;

Jenkins, Marc K. .

IMMUNITY, 2011, 35 (04) :583-595

[90] Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells [J].

Pipkin, Matthew E. ;

Sacks, Jilian A. ;

Cruz-Guilloty, Fernando ;

Lichtenheld, Mathias G. ;

Bevan, Michael J. ;

Rao, Anjana .

IMMUNITY, 2010, 32 (01) :79-90

← 4 5 6 7 8 9 10 11 12 13 →