Transcriptional control of effector and memory CD8+ T cell differentiation

被引：1132

作者：

Kaech, Susan M. ^{[1
,2
]}

Cui, Weiguo ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT 06520 USA

[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 11期

基金：

美国国家卫生研究院;

关键词：

CHEMOKINE RECEPTOR CXCR3; CHRONIC VIRAL-INFECTION; CUTTING EDGE; IN-VIVO; TERMINAL DIFFERENTIATION; MITOCHONDRIAL STAT3; PROTECTIVE IMMUNITY; LINEAGE COMMITMENT; CLONAL EXPANSION; VIRUS-INFECTION;

D O I：

10.1038/nri3307

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.

引用

页码：749 / 761

页数：13

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