Ligand-Controlled Para-Selective C-H Arylation of Monosubstituted Arenes

被引：38

作者：

Xu, Hui ^{[1
]}

Shang, Ming ^{[1
]}

Dai, Hui-Xiong ^{[1
]}

Yu, Jin-Quan ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ORGANIC LETTERS | 2015年 / 17卷 / 15期

基金：

美国国家科学基金会; 中国博士后科学基金;

关键词：

CATALYZED ORTHO-ARYLATION; ELECTRON-DEFICIENT ARENES; BOND ACTIVATION; COUPLING REACTIONS; UNACTIVATED ARENES; SODIUM PERSULFATE; C(SP(2))-H BONDS; COMPLEXES; FUNCTIONALIZATION; PD;

D O I：

10.1021/acs.orglett.5b01802

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In a Pd-catalyzed double C-H activation reaction, a pyridine-type ligand is identified, for the first time, to enable a highly para-selective C-H arylation of monosubstituted arenes. Excellent para-selectivity is achieved with a variety of arenes containing alkyl, methoxyl, and halo substituents.

引用

页码：3830 / 3833

页数：4

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