The Role of Waixenicin A as Transient Receptor Potential Melastatin 7 Blocker

被引：34

作者：

Kim, Byung J. ^{[1
]}

Nam, Joo H. ^{[2
]}

Kwon, Young K. ^{[1
]}

So, Insuk ^{[3
]}

Kim, Seon J. ^{[4
,5
]}

机构：

[1] Pusan Natl Univ, Sch Korean Med, Div Longev & Biofunct Med, Yangsan, South Korea

[2] Dongguk Univ, Coll Med, Dept Physiol, Kyungju, South Korea

[3] Seoul Natl Univ, Coll Med, Dept Physiol, Seoul 110799, South Korea

[4] Hanyang Univ, Ctr Bioartificial Muscle, Seoul 133791, South Korea

[5] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea

来源：

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY | 2013年 / 112卷 / 02期

关键词：

INTERSTITIAL-CELLS; ELECTRICAL RHYTHMICITY; GASTROINTESTINAL-TRACT; TRPM7; CHANNELS; ION CHANNELS; CANCER; CAJAL; PROLIFERATION; MAGNESIUM; CALCIUM;

D O I：

10.1111/j.1742-7843.2012.00929.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transient receptor potential melastatin 7 (TRPM7) plays a role in a number of physiological and pharmacological functions in variety of cells. The aim of this study was to clarify the role for TRPM7 channels and the effect of waixenicin A on the pacemaking activity of interstitial cells of Cajal (ICCs) and on the cell viability of the human gastric and breast adenocarcinoma cell lines, AGS and MCF-7, respectively. Waixenicin A decreased the amplitude of pacemaker potentials in cultured ICC clusters and inhibited TRPM7 currents, but had no effect on Ca2+-activated Cl- conductance (ANO1). Furthermore, waixenicin A was found to inhibit the growth and survival of AGS and MCF-7 cells. These findings indicate that TRPM7 channel modulates intestinal motility and regulates the pathophysiology of human gastric and breast adenocarcinoma cells. These findings suggest that TRPM7 channel be considered a potential target for the treatment of gut motor disorders and gastric and breast cancer.

引用

页码：83 / 89

页数：7

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