Plasma protein adsorption and platelet adhesion onto PEO-entrapped PMMA film surfaces prepared by photo-induced polymerization

Polyethylene oxide (PEO)-entrapped polymethyl methacrylate (PMMA) films were prepared by photo-induced polymerization of methyl methacrylate (MMA) containing 1 similar to 20 wt% of PEO with different molecular weight (400, 10000, and 100000). The photopolymerization was carried out using a 100 W ultraviolet light source(wavelength, 365 nm). The prepared PEO-entrapped PMMA film surfaces were characterized by the measurement of water contact angle and electron spectroscopy for chemical analysis (ESCA). The stability of PEO entrapped in PMMA films was also examined by immersing the films in water for up to 7 days with continuous shaking and measuring the weight changes. The behavior of plasma protein adsorption and platelet adhesion on the PEO-entrapped PMMA film surfaces was investigated. It was observed that the plasma protein adsorption and platelet adhesion on the film surfaces decreased with increasing PEO molecular weight and its surface density. The PEO 100,000-entrapped surfaces with high PEO content were very effective for the prevention of protein adsorption and platelet adhesion.