Cyclic AMP sensor EPAC proteins and energy homeostasis

被引：61
作者：
Almahariq, Muayad [1 ]
Mei, Fang C. [1 ,2 ]
Cheng, Xiaodong [1 ,2 ]
机构：
[1] Univ Texas Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA
[2] Univ Texas Hlth Sci Ctr Houston, Dept Integrat Biol & Pharmacol, Houston, TX 77030 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2014年 / 25卷 / 02期
基金：
美国国家卫生研究院;
关键词：
exchange protein directly activated by cAMP (EPAC); cAMP; energy balance; insulin secretion; leptin resistance; GLUCAGON-LIKE PEPTIDE-1; PROGLUCAGON GENE-EXPRESSION; SELECTIVE CAMP ANALOG; PANCREATIC BETA-CELLS; RAT INS-1 CELLS; STIMULATED INSULIN-SECRETION; GLUCOSE-HOMEOSTASIS; SIGNALING PATHWAYS; LEPTIN RESISTANCE; KINASE-A;
D O I：
10.1016/j.tem.2013.10.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The-pleiotropic second-messenger cAMP plays-a crucial role in mediating the effects of various hormones on metabolism. The major intracellular functions of cAMP are transduced by protein kinase A (PKA) and by exchange proteins directly activated by cAMP (EPACs). The latter act as guanine-nucleotide exchange factors for the RAS-like small G proteins Rap1 and Rap2. Although the role of PKA in regulating energy balance has been extensively studied, the impact of EPACs remains relatively enigmatic. This review summarizes recent genetic and pharmacological studies concerning EPAC involvement in glucose homeostasis and energy balance via the regulation of leptin and insulin signaling pathways. In addition, the development of small-molecule EPAC-specific modulators and their therapeutic potential for the treatment of diabetes and obesity are discussed.
引用
收藏
页码：60 / 71
页数：12
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