STAT3 in immune responses and inflammatory bowel diseases

被引：76
作者：
Fu, XY [1 ]
机构：
[1] Indiana Univ, Sch Med, Dept Microbiol & Immunol, Walther Oncol Ctr, Indianapolis, IN 46202 USA
来源：
CELL RESEARCH | 2006年 / 16卷 / 02期
关键词：
STAT; cytokines; innate and adaptive immunity; inflammation; Crohn's disease; autoimmunity;
D O I：
10.1038/sj.cr.7310029
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
STAT3 has been known as a mediator for gene expression induced by many important cytokines. Recent studies have suggested that STAT3 has important functions in regulation of both innate and adaptive immunity. Loss of STAT3 in immune cells caused severe inflammation in response to pathogens. This review discusses the recent progress and suggests directions for the future research on this interesting molecule.
引用
收藏
页码：214 / 219
页数：6
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