DNA vaccines: ready for prime time?

被引：781

作者：

Kutzler, Michele A. ^{[2
]}

Weiner, David B. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[2] Drexel Univ, Coll Med, Div Infect Dis & HIV Med, Dept Med, Philadelphia, PA 19102 USA

来源：

NATURE REVIEWS GENETICS | 2008年 / 9卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg2432

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since the discovery, over a decade and a half ago, that genetically engineered DNA can be delivered in vaccine form and elicit an immune response, there has been much progress in understanding the basic biology of this platform. A large amount of data has been generated in preclinical model systems, and more sustained cellular responses and more consistent antibody responses are being observed in the clinic. Four DNA vaccine products have recently been approved, all in the area of veterinary medicine. These results suggest a productive future for this technology as more optimized constructs, better trial designs and improved platforms are being brought into the clinic.

引用

页码：776 / 788

页数：13

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