Dynamic release of gentamicin sulfate (GS) from alginate dialdehyde (AD)-crosslinked casein (CAS) films for antimicrobial applications

被引：25
作者：
Bajpai, S. K. [1 ]
Shah, Farhan Ferooz [1 ]
Bajpai, M. [1 ]
机构：
[1] Govt Model Sci Coll, Dept Chem, Polymer Res Lab, Jabalpur, India
来源：
DESIGNED MONOMERS AND POLYMERS | 2017年 / 20卷
关键词：
Hydrogels; wound dressings; alginate dialdehyde; casein; HYDROGEL MEMBRANES; IN-VITRO; KINETICS; MICROSTRUCTURE; NANOPARTICLES; ADSORPTION; DELIVERY;
D O I：
10.1080/15685551.2016.1231037
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In the present work, antibiotic drug gentamicin sulfate (GS) has been loaded into alginate dialdehyde-crosslinked casein (CAS) films for wound dressing applications. The films have been characterized by Fourier transform infrared spectroscopy, X-ray diffraction analysis and scanning electron microscopy. The dynamic release of model drug GS has been investigated in the physiological fluid at 37 degrees C. The drug release data has been interpreted in the terms of various kinetic models such as Power function model, first order model and Schott model. The release data was found to be well fitted by Schott model. The various diffusion coefficients are also evaluated. The adsorption of model therapeutic protein BSA on the film has been investigated. The maximum adsorption is found to be 5.7 mg/cm(2). The films were tested for their antibacterial and anti-fungal action. Finally, the in vivo wound healing study was carried out on Albino wistar rats.
引用
收藏
页码：18 / 32
页数：15
相关论文
共 40 条
[1]   Mathematical modeling for the prediction of the overall swelling profile from poly (AM-co-AA-co-HEA) hydrogels: effect of glycidyl methacrylate and ammonium per sulphate [J].
Awasthi, Seema ;
Singhal, Reena .
INTERNATIONAL JOURNAL OF PLASTICS TECHNOLOGY, 2015, 19 (02) :241-262
[2]   Alginate dialdehyde (AD)-crosslinked casein films: synthesis, characterization and water absorption behavior [J].
Bajpai, S. K. ;
Bajpai, M. ;
Shah, Farhan Ferooz .
DESIGNED MONOMERS AND POLYMERS, 2016, 19 (05) :406-419
[3]   Release characteristics of novel pH-sensitive p(HEMA-DMAEMA) hydrogels containing 3-(trimethoxy-silyl) propyl methacrylate [J].
Brahim, S ;
Narinesingh, D ;
Guiseppi-Elie, A .
BIOMACROMOLECULES, 2003, 4 (05) :1224-1231
[4]   Regenerated cellulose fibre reinforced casein films: Effect of plasticizer and fibres on the film properties [J].
Cho, Sung-Woo ;
Skrifvars, Mikael ;
Hemanathan, Kumar ;
Mahimaisenan, Pirabasenan ;
Adekunle, Kayode .
MACROMOLECULAR RESEARCH, 2014, 22 (07) :701-709
[5]  
Dada A.O., 2012, J APPL CHEM-USSR, V3, P38, DOI [DOI 10.9790/5736-0313845, 10.9790/5736-0313845]
[6]   Effect of Cross-Linking on Microstructure and Physical Performance of Casein Protein [J].
Ghosh, Arun ;
Ali, M. Azam ;
Dias, George J. .
BIOMACROMOLECULES, 2009, 10 (07) :1681-1688
[7]   Controlled Delivery of Vancomycin via Charged Hydrogels [J].
Gustafson, Carl T. ;
Boakye-Agyeman, Felix ;
Brinkman, Cassandra L. ;
Reid, Joel M. ;
Patel, Robin ;
Bajzer, Zeljko ;
Dadsetan, Mahrokh ;
Yaszemski, Michael J. .
PLOS ONE, 2016, 11 (01)
[8]   Structure and properties of cotton fabrics treated with functionalized dialdehyde chitosan [J].
He, Xuemei ;
Tao, Ran ;
Zhou, Tianchi ;
Wang, Chunxia ;
Xie, Kongliang .
CARBOHYDRATE POLYMERS, 2014, 103 :558-565
[9]   SURFACE-ENERGY ANALYSIS OF BIOADHESION [J].
KAELBLE, DH ;
MOACANIN, J .
POLYMER, 1977, 18 (05) :475-482
[10]   Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation [J].
Kamoun, Elbadawy A. ;
Kenawy, El-Refaie S. ;
Tamer, Tamer M. ;
El-Meligy, Mahmoud A. ;
Eldin, Mohamed S. Mohy .
ARABIAN JOURNAL OF CHEMISTRY, 2015, 8 (01) :38-47
1234