Synchronous tumours of the female reproductive tract

被引：25

作者：

Gilks, C. Blake ^{[1
,2
]}

Kommoss, Friedrich ^{[3
]}

机构：

[1] Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada

[2] Vancouver Gen Hosp, Div Anat Pathol, Vancouver, BC, Canada

[3] Inst Pathol, Friedrichshafen, Germany

来源：

PATHOLOGY | 2018年 / 50卷 / 02期

关键词：

Synchronous; independent primaries; metastasis; pseudometastasis; TUBAL INTRAEPITHELIAL CARCINOMA; GRADE SEROUS CARCINOMA; FALLOPIAN-TUBE; CLINICOPATHOLOGICAL ANALYSIS; LYNCH SYNDROME; PSEUDOMYXOMA PERITONEI; ENDOMETRIAL CANCER; PRIMARY NEOPLASMS; MUCINOUS OVARIAN; PAGETS-DISEASE;

D O I：

10.1016/j.pathol.2017.10.007

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Many ovarian endometrioid carcinomas present with concurrent endometrial carcinoma, and these organ-confined, low-grade synchronous endometrial and ovarian tumours consistently behave as independent primary tumours, rather than a single advanced-stage carcinoma; they are associated with a very favourable prognosis and there is no need for adjuvant treatment. This phenomenon of synchronous tumours involving two or more sites within the female reproductive tract is well recognised, occurring in 1-2% of cases. Although some tumours can be recognised as metastasis, in many the relationship between the synchronous tumours is uncertain. Recently, application of next generation sequencing to synchronous endometrial and ovarian carcinomas has shed light on the relationship between these tumours, but raised more questions about the biology of this curious phenomenon. Herein, we review synchronous tumours involving more than one site in the female genital tract, discuss the pathogenesis, and offer guidelines for how to handle in routine practice.

引用

页码：214 / 221

页数：8

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