Aqueous microwave-assisted one-pot synthesis of N-substituted rhodanines

被引：40
|
作者：
Nitsche, Christoph [1 ]
Klein, Christian D. [1 ]
机构：
[1] Heidelberg Univ, Inst Pharm & Mol Biotechnol IPMB, D-69120 Heidelberg, Germany
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 39期
关键词：
Rhodanine; Microwave; Multicomponent reaction; Green chemistry; Cyclization; 3-COMPONENT; CHEMISTRY;
D O I：
10.1016/j.tetlet.2012.07.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two aqueous, one-pot, microwave-assisted methods for the rapid synthesis of N-substituted rhodanines from amine substrates are described. Alkyl- and benzylamines could be converted into the corresponding rhodanines with an atom-efficient one-pot, three-step protocol based on carbon disulfide and chloroacetic acid in short reaction times and good to excellent yields. An alternative, microwave-assisted one-pot, one-step protocol using bis(carboxymethyl)trithiocarbonate in water was developed for the synthesis of N-arylrhodanines from anilines. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5197 / 5201
页数：5
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