Direct Decarboxylative Meta-Selective Acylation of Arenes via an Ortho-Ruthenation Strategy

被引：64

作者：

Jing, Kun ^{[1
,2
]}

Li, Zhong-Yuan ^{[1
,2
]}

Wang, Guan-Wu ^{[1
,2
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, CAS Key Lab Soft Matter Chem, Collaborat Innovat Ctr Chem Energy Mat iChEM,Ctr, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China

来源：

ACS CATALYSIS | 2018年 / 8卷 / 12期

关键词：

meta-selectivity; decarboxylative acylation; ruthenium catalysis; ortho-metalation; alpha-oxocarboxylic acids; radical process; H BOND FUNCTIONALIZATION; ALPHA-OXOCARBOXYLIC ACIDS; AROMATIC KETONES; ALKYLATION; ACTIVATION; NITRATION; DIFLUOROMETHYLATION; REGIOSELECTIVITY; BROMINATION; SECONDARY;

D O I：

10.1021/acscatal.8b03695

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The direct decarboxylative meta-selective C-H acylation of a wide range of arenes is established via the ruthenium-catalyzed ortho-metalation strategy. This procedure, using Ru-3(CO)(12) as the catalyst and a-oxocarboxylic acids as the acylation source, featured broad substrate scope, good functional group tolerance, and high regioselectivity. Mechanistic studies demonstrated that a radical process and an 18e-octahedral ruthenium species were involved in this reaction. The present work provides a new strategy for the regioselective metaacylation reactions and will be a powerful tool for the development of pharmaceutical and materials science.

引用

页码：11875 / 11881

页数：13

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