Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for First Relapse of Ovarian Cancer

被引：0

作者：

Classe, Jean-Marc ^{[1
]}

Glehen, Olivier ^{[2
,3
]}

Decullier, Evelyne ^{[4
,5
,6
]}

Bereder, Jean Marc ^{[7
]}

Msika, Simon ^{[8
]}

Lorimier, Gerard ^{[9
]}

Abboud, Karine ^{[10
]}

Meeus, Pierre ^{[11
]}

Ferron, Gwenael ^{[12
]}

Quenet, Francois ^{[13
]}

Marchal, Frederic ^{[14
]}

Gouy, Sebastien ^{[15
]}

Pomel, Christophe ^{[16
]}

Pocard, Marc ^{[17
]}

Guyon, Frederic ^{[18
]}

Bakrin, Naoual ^{[2
]}

机构：

[1] Inst Cancerol Ouest, Ctr Rene Gauducheau, F-44805 St Herblain, France

[2] Univ Lyon 1, EMR 3738, F-69622 Villeurbanne, France

[3] Hop Lyon Sud, Pierre Benite, France

[4] Hosp Civils Lyon, Pole IMER, Unite Methodol Rech Clin, Lyon, France

[5] Univ Lyon, RECIF, EAM Sante Individu Soc, Lyon, France

[6] Univ Lyon 1, F-69365 Lyon, France

[7] Ctr Hosp Archet II, Nice, France

[8] Hop Louis Mourier, F-92701 Colombes, France

[9] Inst Cancerol Ouest, Ctr Paul Papin, Angers, France

[10] Hop Nord St Priest Jarez, St Priest En Jarez, France

[11] Ctr Leon Berard, Laennec, France

[12] IUCT Oncopole, Toulouse, France

[13] Ctr Val dAurelle, Montpellier, France

[14] Inst Cancerol Lorraine, Vandoeuvre Les Nancy, France

[15] Inst Gustave Roussy, Villejuif, France

[16] Ctr Jean Perrin, Clermont Ferrand, France

[17] Hop Lariboisiere, F-75475 Paris, France

[18] Inst Bergonie, Bordeaux, France

来源：

ANTICANCER RESEARCH | 2015年 / 35卷 / 09期

关键词：

Ovarian cancer relapse; hyperthermic intra-peritoneal chemotherapy; secondary surgery; PERITONEAL CARCINOMATOSIS; RESIDUAL DISEASE; SURVIVAL; HIPEC; MULTICENTER; CARBOPLATIN; TRIAL;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: To assess impact of surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients treated for a first relapse of ovarian cancer (FROC). Patients and Methods: Patients with a FROC treated with second-line chemotherapy, surgery and HIPEC were retrospectively included from 13 Institutions. Studied parameters were interval free between the end of initial treatment and the first relapse, second-line chemotherapy, peritoneal cancer index and completeness of surgery, HIPEC, mortality and morbidity, pathological results and survival. Results: From 2001 to 2010, 314 patients were included. The main strategy was secondary chemotherapy followed by surgery and HIPEC (269/314-85.6%). Mortality and morbidity rates were respectively 1% and 30.9%. Median follow-up was 50 months, 5-year overall survival was 38.0%, with no difference between platinum-sensitive or -resistant patients and 5-year disease-free survival was 14%. Conclusion: HIPEC allows encouraging survival in the treatment of FROC, better in case of complete surgery, with acceptable mortality and morbidity rates.

引用

页码：4997 / 5005

页数：9

共 29 条

[1] Peritoneal carcinomatosis treated with cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for advanced ovarian carcinoma: A French multicentre retrospective cohort study of 566 patients [J].

Bakrin, N. ;

Bereder, J. M. ;

Decullier, E. ;

Classe, J. M. ;

Msika, S. ;

Lorimier, G. ;

Abboud, K. ;

Meeus, P. ;

Ferron, G. ;

Quenet, F. ;

Marchal, F. ;

Gouy, S. ;

Morice, P. ;

Pomel, C. ;

Pocard, M. ;

Guyon, F. ;

Porcheron, J. ;

Glehen, O. .

EJSO, 2013, 39 (12) :1435-1443

[2] Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Persistent and Recurrent Advanced Ovarian Carcinoma: A Multicenter, Prospective Study of 246 Patients [J].

Bakrin, N. ;

Cotte, E. ;

Golfier, F. ;

Gilly, F. N. ;

Freyer, G. ;

Helm, W. ;

Glehen, O. ;

Bereder, J. M. .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (13) :4052-4058

[3] Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study [J].

Berrino, Franco ;

De Angelis, Roberta ;

Sant, Milena ;

Rosso, Stefano ;

Lasota, Magdalena B. ;

Coebergh, Jan W. ;

Santaquilani, Mariano .

LANCET ONCOLOGY, 2007, 8 (09) :773-783

[4] What is the optimal goal of primary cytoreductive surgery for bulky stage IIIC epithelial ovarian carcinoma (EOC)? [J].

Chi, D. S. ;

Eisenhauer, E. L. ;

Lang, J. ;

Huh, J. ;

Haddad, L. ;

Abu-Rustum, N. R. ;

Sonoda, Y. ;

Levine, D. A. ;

Hensley, M. ;

Barakat, R. R. .

GYNECOLOGIC ONCOLOGY, 2006, 103 (02) :559-564

[5] Should the Treatment of Peritoneal Carcinomatosis by Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Still be Regarded as a Highly Morbid Procedure? A Systematic Review of Morbidity and Mortality [J].

Chua, Terence C. ;

Yan, Tristan D. ;

Saxena, Akshat ;

Morris, David L. .

ANNALS OF SURGERY, 2009, 249 (06) :900-907

[6] Cytoreductive surgery and intraperitoneal chemohyperthermia for chemoresistant and recurrent advanced epithelial ovarian cancer: Prospective study of 81 patients [J].

Cotte, Eddy ;

Glehen, Olivier ;

Mohamed, Faheez ;

Lamy, Franck ;

Falandry, Claire ;

Golfier, Francois ;

Gilly, Francois Noel .

WORLD JOURNAL OF SURGERY, 2007, 31 (09) :1813-1821

[7] Role of Surgical Outcome as Prognostic Factor in Advanced Epithelial Ovarian Cancer: A Combined Exploratory Analysis of 3 Prospectively Randomized Phase 3 Multicenter Trials By the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and the Groupe d'Investigateurs Nationaux Pour les Etudes des Cancers de l'Ovaire (GINECO) [J].

du Bois, Andreas ;

Reuss, Alexander ;

Pujade-Lauraine, Eric ;

Harter, Philipp ;

Ray-Coquard, Isabelle ;

Pfisterer, Jacobus .

CANCER, 2009, 115 (06) :1234-1244

[8] HIPEC in recurrent ovarian cancer patients: Morbidity-related treatment and long-term analysis of clinical outcome [J].

Fagotti, Anna ;

Costantini, Barbara ;

Vizzielli, Giuseppe ;

Perelli, Federica ;

Ercoli, Alfredo ;

Gallotta, Valerio ;

Scambia, Giovanni ;

Fanfani, Francesco .

GYNECOLOGIC ONCOLOGY, 2011, 122 (02) :221-225

[9] Prediction of 30-day morbidity after primary cytoreductive surgery for advanced stage ovarian cancer [J].

Gerestein, C. G. ;

Nieuwenhuyzen-de Boer, G. M. ;

Eijkemans, M. J. ;

Kooi, G. S. ;

Burger, C. W. .

EUROPEAN JOURNAL OF CANCER, 2010, 46 (01) :102-109

[10] Causes of postoperative mortality after surgery for ovarian cancer [J].

Gerestein, C. G. ;

Damhuis, R. A. M. ;

de Vries, M. ;

Reedijk, A. ;

Burger, C. W. ;

Kooi, G. S. .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (16) :2799-2803

← 1 2 3 →