Wnt-7a Stimulates Dendritic Spine Morphogenesis and PSD-95 Expression Through Canonical Signaling

被引：28

作者：

Ramos-Fernandez, Eva ^{[1
]}

Tapia-Rojas, Cheril ^{[1
]}

Ramirez, Valerie T. ^{[1
]}

Inestrosa, Nibaldo C. ^{[1
,2
,3
]}

机构：

[1] Pontificia Univ Catolica, Ctr Envejecimiento & Regenerac CARE UC, Dept Biol Celular & Mol, Fac Ciencias Biol,Lab Neurobiol Mol, Santiago 8331150, Chile

[2] Univ New South Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Fac Med, Sydney, NSW, Australia

[3] Univ Magallanes, Ctr Excelencia Biomed Magallanes CEBIMA, Punta Arenas 6200000, Chile

来源：

MOLECULAR NEUROBIOLOGY | 2019年 / 56卷 / 03期

关键词：

Wnt signaling; Dendritic spine plasticity; PSD-95; TCF; LEF; SYNAPTIC DIFFERENTIATION; PATHWAY; PROTEIN; INHIBITION; FAMILY; TRANSMISSION; RECEPTORS; INCREASES; PROMOTES; DENSITY;

D O I：

10.1007/s12035-018-1162-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Wnt signaling regulates brain development and synapse maturation; however, the precise molecular mechanism remains elusive. Here, we report that Wnt-7a stimulates dendritic spine morphogenesis in the hippocampus via glycogen synthase kinase-3 (GSK-3) inhibition, triggering -catenin/T cell factor/lymphoid enhancer factor (TCF/LEF)-dependent gene transcription and promoting postsynaptic density-95 (PSD-95) protein expression. In addition, wild-type mice treated with an inhibitor of -catenin/TCF/LEF-mediated transcription showed a reduction in spatial memory acquisition accompanied by a reduction in PSD-95 and decreases in spine density measured by Golgi staining, suggesting that PSD-95 is a novel Wnt target gene. Together, our data strongly demonstrate that Wnt-dependent target gene transcription is essential to hippocampal synaptic plasticity.

引用

页码：1870 / 1882

页数：13

共 60 条

[1] Calcium/Calmodulin-Dependent Protein Kinase Type IV Is a Target Gene of the Wnt/β-Catenin Signaling Pathway [J].