Plasma amyloid beta measurements - a desired but elusive Alzheimer's disease biomarker

被引：108

作者：

Toledo, Jon B. ^{[1
]}

Shaw, Leslie M. ^{[1
]}

Trojanowski, John Q. ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Inst Aging,Ctr Neurodegenerat Dis Res, Philadelphia, PA 19104 USA

来源：

ALZHEIMERS RESEARCH & THERAPY | 2013年 / 5卷 / 02期

关键词：

GAMMA-SECRETASE INHIBITOR; A-BETA; PRECURSOR PROTEIN; PEPTIDE; 1-42; DEMENTIA; RISK; TOLERABILITY; ONSET; ASSOCIATION; ADULTS;

D O I：

10.1186/alzrt162

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebrospinal fluid and positron emission tomography biomarkers accurately predict an underlying Alzheimer's disease (AD) pathology; however, they represent either invasive or expensive diagnostic tools. Therefore, a blood-based biomarker like plasma amyloid beta (A beta) that could correlate with the underlying AD pathology and serve as a prognostic biomarker or an AD screening strategy is urgently needed as a cost-effective and non-invasive diagnostic tool. In this paper we review the demographic, biologic, genetic and technical aspects that affect plasma A beta levels. Findings of cross-sectional and longitudinal studies of plasma A beta, including autosomal dominant AD cases, sporadic AD cases, Down syndrome cases and population studies, are also discussed. Finally, we review the association between cerebrovascular disease and A beta plasma levels and the responses observed in clinical trials. Based on our review of the current literature on plasma A beta, we conclude that further clinical research and assay development are needed before measures of plasma A beta can be interpreted so they can be applied as trait, risk or state biomarkers for AD.

引用

页数：10

共 79 条

[1]

[Anonymous], MOL PSYCHIAT

[2] DEFINED NEUROFILAMENT, TAU-AMYLOID AND BETA-AMYLOID PRECURSOR PROTEIN EPITOPES DISTINGUISH ALZHEIMER FROM NON-ALZHEIMER SENILE PLAQUES [J].

ARAI, H ;

LEE, VMY ;

OTVOS, L ;

GREENBERG, BD ;

LOWERY, DE ;

SHARMA, SK ;

SCHMIDT, ML ;

TROJANOWSKI, JQ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (06) :2249-2253

[3] EXPRESSION PATTERNS OF BETA-AMYLOID PRECURSOR PROTEIN (BETA-APP) IN NEURAL AND NONNEURAL HUMAN TISSUES FROM ALZHEIMERS-DISEASE AND CONTROL SUBJECTS [J].

ARAI, H ;

LEE, VMY ;

MESSINGER, ML ;

GREENBERG, BD ;

LOWERY, DE ;

TROJANOWSKI, JQ .

ANNALS OF NEUROLOGY, 1991, 30 (05) :686-693

[4] Serum creatinine levels correlate with plasma amyloid β protein [J].

Arvanitakis, Z ;

Lucas, JA ;

Younkin, LH ;

Younkin, SG ;

Graff-Radford, NR .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2002, 16 (03) :187-190

[5] Plasma levels of amyloid β-protein 42 are increased in women with mild cognitive impairment [J].

Assini, A ;

Cammarata, S ;

Vitali, A ;

Colucci, M ;

Giliberto, L ;

Borghi, R ;

Inglese, ML ;

Volpe, S ;

Ratto, S ;

Dagna-Bricarelli, F ;

Baldo, C ;

Argusti, A ;

Odetti, P ;

Piccini, A ;

Tabaton, M .

NEUROLOGY, 2004, 63 (05) :828-831

[6] Stability of amyloid-β peptides in plasma and serum [J].

Bibl, Mirko ;

Welge, Volker ;

Esselmann, Hermann ;

Wiltfang, Jens .

ELECTROPHORESIS, 2012, 33 (03) :445-450

[7] Plasma Amyloid Beta-42 Independently Predicts Both Late-Onset Depression and Alzheimer Disease [J].

Blasko, Imrich ;

Kemmler, Georg ;

Jungwirth, Susanne ;

Wichart, Ildiko ;

Krampla, Wolfgang ;

Weissgram, Silvia ;

Jellinger, Kurt ;

Tragl, Karl Heinz ;

Fischer, Peter .

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2010, 18 (11) :973-982

[8] Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance [J].

Castellano, Joseph M. ;

Kim, Jungsu ;

Stewart, Floy R. ;

Jiang, Hong ;

DeMattos, Ronald B. ;

Patterson, Bruce W. ;

Fagan, Anne M. ;

Morris, John C. ;

Mawuenyega, Kwasi G. ;

Cruchaga, Carlos ;

Goate, Alison M. ;

Bales, Kelly R. ;

Paul, Steven M. ;

Bateman, Randall J. ;

Holtzman, David M. .

SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (89)

[9] Use of Florbetapir-PET for Imaging β-Amyloid Pathology [J].

Clark, Christopher M. ;

Schneider, Julie A. ;

Bedell, Barry J. ;

Beach, Thomas G. ;

Bilker, Warren B. ;

Mintun, Mark A. ;

Pontecorvo, Michael J. ;

Hefti, Franz ;

Carpenter, Alan P. ;

Flitter, Matthew L. ;

Krautkramer, Michael J. ;

Kung, Hank F. ;

Coleman, R. Edward ;

Doraiswamy, P. Murali ;

Fleisher, Adam S. ;

Sabbagh, Marwan N. ;

Sadowsky, Carl H. ;

Reiman, P. Eric M. ;

Zehntner, Simone P. ;

Skovronsky, Daniel M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (03) :275-283

[10] Plasma β amyloid and the risk of Alzheimer's disease in Down syndrome [J].

Coppus, Antonia M. W. ;

Schuur, Maaike ;

Vergeer, Jeanet ;

Janssens, A. Cecile J. W. ;

Oostra, Ben A. ;

Verbeek, Marcel M. ;

van Duijn, Cornelia M. .

NEUROBIOLOGY OF AGING, 2012, 33 (09) :1988-1994

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