Role of intracanalicular volumetric and dosimetric parameters on hearing preservation after vestibular schwannoma radiosurgery

被引:71
作者
Massager, N
Nissim, O
Delbrouck, C
Devriendt, D
David, P
Desmedt, F
Wikler, D
Hassid, S
Brotchi, J
Levivier, M
机构
[1] Free Univ Brussels, Hop Erasme, Gamma Knife Ctr, B-1070 Brussels, Belgium
[2] Free Univ Brussels, Hop Erasme, Dept Ear Nose & Throat, B-1070 Brussels, Belgium
[3] Free Univ Brussels, Inst Jules Bordet, Phys Lab, B-1070 Brussels, Belgium
[4] Free Univ Brussels, Inst Jules Bordet, Dept Radiat Therapy, B-1070 Brussels, Belgium
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2006年 / 64卷 / 05期
关键词
gamma knife; radiosurgery; vestibular schwannoma; hearing; dosimetry;
D O I
10.1016/j.ijrobp.2005.10.030
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To analyze the relationship between hearing preservation after gamma knife radiosurgery (GKR) for vestibular schwannoma (VS) and some volumetric and dosimetric parameters of the intracanalicular components of VS. Methods and Materials: This study included 82 patients with a VS treated by GKR; all patients had no NF2 disease, a Gardner-Robertson hearing class 1-4 before treatment, a marginal dose of 12 Gy, and a radiologic and audiologic follow-up >= 1 year post-GKR. The volume of both the entire tumor and the intracanalicular part of the tumor and the mean and integrated dose of these two volumes were correlated to the auditory outcomes of patients. Results: At last hearing follow-up, 52 patients had no hearing worsening, and 30 patients had an increase of >= 1 class on Gardner-Robertson classification. We found that hearing preservation after GKR is significantly correlated with the intracanalicular tumor volume, as well as with the integrated dose delivered to the intracanalicular tumor volume. Conclusions: Some volumetric and dosimetric parameters of the intracanalicular part of the tumor influence hearing preservation after GKR of VS. Consequently, we advise the direct treatment of patients with preserved functional hearing and a VS including a small intracanalicular volume. (c) 2006 Elsevier Inc.
引用
收藏
页码:1331 / 1340
页数:10
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