Endometrial expression of selected genes in patients achieving pregnancy spontaneously or after ICSI and patients failing at least two ICSI cycles

被引：10
作者：
Allegra, Adolfo [1 ]
Marino, Angelo [1 ]
Caballero Peregrin, Pedro [2 ]
Lama, Anna [1 ]
Garcia-Segovia, Aurea [2 ]
Forte, Giusi Irma [1 ]
Nunez-Calonge, Rocio [2 ]
Agueli, Cecilia [3 ]
Mazzola, Sergio [4 ]
Volpes, Aldo [1 ]
机构：
[1] Andros Day Surg, Reprod Med Unit, I-90144 Palermo, Italy
[2] Tambre Clin, Reprod Unit, Madrid 28002, Spain
[3] Villa Sofia Cervello Hosp, Haematol Lab, I-90146 Palermo, Italy
[4] Andros Day Surg, Med Stat Unit, I-90144 Palermo, Italy
来源：
REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 25卷 / 05期
关键词：
endometrium; gene expression profile; implantation window; pregnancy; LEUKEMIA INHIBITORY FACTOR; HUMAN EMBRYO IMPLANTATION; IN-VITRO-FERTILIZATION; OVARIAN STIMULATION; UNEXPLAINED INFERTILITY; CLINICAL-IMPLICATIONS; OOCYTE RETRIEVAL; MENSTRUAL-CYCLE; CANDIDATE GENES; NATURAL CYCLE;
D O I：
10.1016/j.rbmo.2012.07.019
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The objective of this study was to identify the endometrial gene expression profile in receptive phase, which could represent a useful prognostic tool for selecting IVF patients. Endometrial expression of 47 selected genes biopsied during the window of implantation in natural cycles was compared between patients who achieved a successful pregnancy spontaneously or after subsequent intracytoplasmic sperm injection (ICSI) cycles and patients who did not achieve a pregnancy after at least two failed ICSI cycles. The comparative analysis showed significantly different levels of expression in 19 genes, five implicated in apoptosis (CASP8, FADD, CASP10, APAF1, ANXA4), three in immunity (LIF, SPP1, C4BPA), five in transcriptional activity (MSX1, HOXA10, MSX2, HOXA11, GATA2), two in lipid metabolism (LEPR, APOD) and four in oxidative metabolism (AOX1, ALDH1A3, GPX3, NNMT). The evidence for these genes being differently expressed could represent the starting point of identifying the ideal receptive endometrial gene expression profile, which could be used in the future as a prognostic tool for IVF patients. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：481 / 491
页数：11
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