Endometrial expression of selected genes in patients achieving pregnancy spontaneously or after ICSI and patients failing at least two ICSI cycles

被引：10

作者：

Allegra, Adolfo ^{[1
]}

Marino, Angelo ^{[1
]}

Caballero Peregrin, Pedro ^{[2
]}

Lama, Anna ^{[1
]}

Garcia-Segovia, Aurea ^{[2
]}

Forte, Giusi Irma ^{[1
]}

Nunez-Calonge, Rocio ^{[2
]}

Agueli, Cecilia ^{[3
]}

Mazzola, Sergio ^{[4
]}

Volpes, Aldo ^{[1
]}

机构：

[1] Andros Day Surg, Reprod Med Unit, I-90144 Palermo, Italy

[2] Tambre Clin, Reprod Unit, Madrid 28002, Spain

[3] Villa Sofia Cervello Hosp, Haematol Lab, I-90146 Palermo, Italy

[4] Andros Day Surg, Med Stat Unit, I-90144 Palermo, Italy

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2012年 / 25卷 / 05期

关键词：

endometrium; gene expression profile; implantation window; pregnancy; LEUKEMIA INHIBITORY FACTOR; HUMAN EMBRYO IMPLANTATION; IN-VITRO-FERTILIZATION; OVARIAN STIMULATION; UNEXPLAINED INFERTILITY; CLINICAL-IMPLICATIONS; OOCYTE RETRIEVAL; MENSTRUAL-CYCLE; CANDIDATE GENES; NATURAL CYCLE;

D O I：

10.1016/j.rbmo.2012.07.019

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The objective of this study was to identify the endometrial gene expression profile in receptive phase, which could represent a useful prognostic tool for selecting IVF patients. Endometrial expression of 47 selected genes biopsied during the window of implantation in natural cycles was compared between patients who achieved a successful pregnancy spontaneously or after subsequent intracytoplasmic sperm injection (ICSI) cycles and patients who did not achieve a pregnancy after at least two failed ICSI cycles. The comparative analysis showed significantly different levels of expression in 19 genes, five implicated in apoptosis (CASP8, FADD, CASP10, APAF1, ANXA4), three in immunity (LIF, SPP1, C4BPA), five in transcriptional activity (MSX1, HOXA10, MSX2, HOXA11, GATA2), two in lipid metabolism (LEPR, APOD) and four in oxidative metabolism (AOX1, ALDH1A3, GPX3, NNMT). The evidence for these genes being differently expressed could represent the starting point of identifying the ideal receptive endometrial gene expression profile, which could be used in the future as a prognostic tool for IVF patients. (C) 2012, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

引用

页码：481 / 491

页数：11

共 71 条

[1] Immunology of normal pregnancy [J].

Aagaard-Tillery, Kjersti M. ;

Silver, Robert ;

Dalton, Jess .

SEMINARS IN FETAL & NEONATAL MEDICINE, 2006, 11 (05) :279-295

[2] Leukemia inhibitory factor and human embryo implantation [J].

Aghajanova, L .

UTERUS AND HUMAN REPRODUCTION, 2004, 1034 :176-183

[3] Update on the role of leukemia inhibitory factor in assisted reproduction [J].

Aghajanova, Lusine .

CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 2010, 22 (03) :213-219

[4] The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes [J].

Al-Gubory, Kais H. ;

Fowler, Paul A. ;

Garrel, Catherine .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (10) :1634-1650

[5] The endometrium as a novel target for leptin: differences in fertility and subfertility [J].

Alfer, J ;

Muller-Schottle, F ;

Classen-Linke, I ;

von Rango, U ;

Happel, L ;

Beier-Hellwig, K ;

Rath, W ;

Beier, HM .

MOLECULAR HUMAN REPRODUCTION, 2000, 6 (07) :595-601

[6] Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle? [J].

Allegra, A. ;

Marino, A. ;

Coffaro, F. ;

Lama, A. ;

Rizza, G. ;

Scaglione, P. ;

Sammartano, F. ;

Santoro, A. ;

Volpes, A. .

HUMAN REPRODUCTION, 2009, 24 (10) :2549-2557

[7] Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility [J].

Altmae, S. ;

Martinez-Conejero, J. A. ;

Salumets, A. ;

Simon, C. ;

Horcajadas, J. A. ;

Stavreus-Evers, A. .

MOLECULAR HUMAN REPRODUCTION, 2010, 16 (03) :178-187

[8] Research Resource: Interactome of Human Embryo Implantation: Identification of Gene Expression Pathways, Regulation, and Integrated Regulatory Networks [J].

Altmae, Signe ;

Reimand, Jueri ;

Hovatta, Outi ;

Zhang, Pu ;

Kere, Juha ;

Laisk, Triin ;

Saare, Merli ;

Peters, Maire ;

Vilo, Jaak ;

Stavreus-Evers, Anneli ;

Salumets, Andres .

MOLECULAR ENDOCRINOLOGY, 2012, 26 (01) :203-217

[9] Deliveries and children born after in-vitro fertilisation in Sweden 1982-95:: a retrospective cohort study [J].

Bergh, T ;

Ericson, A ;

Hillensjö, T ;

Nygren, KG ;

Wennerholm, UB .

LANCET, 1999, 354 (9190) :1579-1585

[10] Gene expression in cultured endometrium from women with different outcomes following IVF [J].

Bersinger, Nick A. ;

Wunder, Dorothea M. ;

Birkhaeuser, Martin H. ;

Mueller, Michael D. .

MOLECULAR HUMAN REPRODUCTION, 2008, 14 (08) :475-484

← 1 2 3 4 5 6 7 8 →