Factors that influence adult neurogenesis as potential therapy

被引：143

作者：

Shohayeb, Belal ^{[1
]}

Diab, Mohamed ^{[2
]}

Ahmed, Mazen ^{[2
]}

Dominic Chi Hiung Ng ^{[1
]}

机构：

[1] Univ Queensland, Fac Med, Sch Biomed Sci, St Lucia, Qld 4067, Australia

[2] Pharos Univ Alexandria, Fac Pharm, POB Sidi Gaber, Alexandria 21311, Egypt

来源：

TRANSLATIONAL NEURODEGENERATION | 2018年 / 7卷

关键词：

Niche; Neurotrophins; Cytokines; Transcription factors; Stem cells; Extrinsic factors; Therapy; NEURAL STEM-CELLS; NERVE GROWTH-FACTOR; CILIARY NEUROTROPHIC FACTOR; HIPPOCAMPAL NEUROGENESIS; DENTATE GYRUS; SUBVENTRICULAR ZONE; SYNAPTIC PLASTICITY; PROGENITOR CELLS; VASCULAR NICHE; IN-VITRO;

D O I：

10.1186/s40035-018-0109-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adult neurogenesis involves persistent proliferative neuroprogenitor populations that reside within distinct regions of the brain. This phenomenon was first described over 50 years ago and it is now firmly established that new neurons are continually generated in distinct regions of the adult brain. The potential of enhancing the neurogenic process lies in improved brain cognition and neuronal plasticity particularly in the context of neuronal injury and neurodegenerative disorders. In addition, adult neurogenesis might also play a role in mood and affective disorders. The factors that regulate adult neurogenesis have been broadly studied. However, the underlying molecular mechanisms of regulating neurogenesis are still not fully defined. In this review, we will provide critical analysis of our current understanding of the factors and molecular mechanisms that determine neurogenesis. We will further discuss pre-clinical and clinical studies that have investigated the potential of modulating neurogenesis as therapeutic intervention in neurodegeneration.

引用

页数：19

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