Synthesis of 3,4-Disubstituted Maleimides by Selective Cross-Coupling Reactions Using Indium Organometallics

被引：48

作者：

Bouissane, Latifa ^{[1
]}

Perez Sestelo, Jose ^{[1
]}

Sarandeses, Luis A. ^{[1
]}

机构：

[1] Univ A Coruna, Dept Quim Fundamental, E-15071 La Coruna, Spain

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 06期

关键词：

GLYCOGEN-SYNTHASE KINASE-3; BIOLOGICAL EVALUATION; TRIORGANOINDIUM REAGENTS; CONVENIENT SYNTHESIS; NATURAL-PRODUCTS; INHIBITORS; ANALOGS; REBECCAMYCIN; DERIVATIVES; POTENT;

D O I：

10.1021/ol900063p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Unsymmetrical 3,4-disubstituted maleimides have been synthesized by palladium-catalyzed cross-coupling reactions of indium organometallics with 3,4-dihalomaleimides. The synthesis was performed by stepwise or sequential one-pot palladium-catalyzed cross-coupling reactions with various triorganoindium reagents. This method was used to prepare a wide variety of alkyl, aryl, heteroaryl, and alkynyl 3,4-disubstituted maleimides in good yields and with high selectivity and atom economy.

引用

页码：1285 / 1288

页数：4

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