ARFI Variance of Acceleration (VoA) for Noninvasive Characterization of Human Carotid Plaques In Vivo

被引：0

作者：

Torres, Gabriela ^{[1
,2
]}

Czernuszewicz, Tomasz J. ^{[1
,2
]}

Homeister, Jonathon W. ^{[3
]}

Farber, Mark A. ^{[4
]}

Gallippi, Caterina M. ^{[1
,2
]}

机构：

[1] Univ North Carolina Chapel Hill, Joint Dept Biomed Engn, Chapel Hill, NC 27599 USA

[2] North Carolina State Univ, Raleigh, NC 27695 USA

[3] Univ N Carolina, Dept Pathol & Lab Med, Chapel Hill, NC USA

[4] Univ N Carolina, Dept Surg, Chapel Hill, NC USA

来源：

2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC) | 2017年

关键词：

SUBCUTANEOUS HEMORRHAGE ASSH; ULTRASOUND; SURVEILLANCE; DOGS;

D O I：

暂无

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Rather than degree of stenosis, assessing plaque structure and composition is relevant to discerning risk for plaque rupture with downstream ischemic event. The structure and composition of carotid plaque has been assessed noninvasively using Acoustic Radiation Force Impulse (ARFI) ultrasound imaging. In particular, ARFI-derived peak displacement (PD) estimations have been demonstrated for discriminating soft (lipid rich necrotic core (LRNC) or intraplaque hemorrhage (IPH)) from stiff (collagen (COL) or calcium (CAL)) plaque features; however, PD did not differentiate LRNC from IPH or COL from CAL. The purpose of this study is to evaluate a new ARFI-based measurement, the variance of acceleration (VoA), for differentiating among soft and stiff plaque components. Both PD and VoA results were obtained in vivo for a human carotid plaque acquired in a previous study and matched to a histological standard analyzed by a pathologist. With VoA, plaque feature contrast was increased by an average of 60% in comparison to PD.

引用

页码：2984 / 2987

页数：4