Determination and Correlation of Solubility of Cefradine Form I in Five Pure Solvents from (283.15 to 308.15) K

被引：16

作者：

Hu, Xiaowei ^{[1
]}

Wang, Yongli ^{[1
,2
]}

Xie, Chuang ^{[1
]}

Wang, Guan ^{[1
]}

Hao, Hongxun ^{[1
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Tianjin Key Lab Modern Drug Delivery & High Effic, Tianjin 300072, Peoples R China

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2013年 / 58卷 / 07期

基金：

美国国家科学基金会;

关键词：

INTRINSIC SOLUBILITY; METHANOL; ETHANOL;

D O I：

10.1021/je400218d

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The solubility of cefradine form I in five pure solvents from (283.15 to 308.15) K was experimentally determined by using an equilibrium method. It was found that the solubility of cefradine form I in all tested solvents increased with the increase of temperature. Four thermodynamic models were used to correlate the experimental, solubility data. The infinite-dilution activity coefficient and mixing properties including the mixing free Gibbs energy, enthalpy, and entropy of cefradine form I solution were also calculated by using the nonrandom two-liquid (NRTL) model. It was found that the correlated results by the van't Hoff equation, the modified Apelblat equation, and the NRTL model agreed well with the experimental data.

引用

页码：2028 / 2034

页数：7

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