A facile and efficient synthesis of 2,2,2-trifluoroethyl 2-[(E)-N-phenylcinnamamido]-2-phenylacetates in trifluoroethanol via sequential Ugi four-component reaction/esterification

被引：12
|
作者：
Balalaie, Saeed [1 ]
Motaghedi, Hassan [1 ]
Tahmassebi, Daryoush [2 ]
Bararjanian, Morteza [1 ]
Bijanzadeh, Hamid Reza [1 ,3 ]
机构：
[1] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran
[2] Indiana Univ Purdue Univ, Dept Chem, Ft Wayne, IN 46805 USA
[3] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
来源：
TETRAHEDRON LETTERS | 2012年 / 53卷 / 46期
关键词：
Ugi-4CR; Trifluoroethanol; Sequential Ugi-4CR/trifluoroethyl esterification; CATALYZED OXIDATIVE AMINOCARBONYLATION; STEREOSELECTIVE-SYNTHESIS; MULTICOMPONENT REACTIONS; CONVENIENT SYNTHESIS; TYROSINE KINASE; 3-ALKYLIDENEOXINDOLES; DERIVATIVES; INHIBITORS;
D O I：
10.1016/j.tetlet.2012.08.096
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe an efficient approach for the synthesis of N-substituted 2-alkenylamides in trifluoroethanol via an Ugi 4-component reaction in short reaction times. The use of a catalytic amount of sulfuric acid in trifluoroethanol gave the desired trifluoroethyl derivatives in good to high yields. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6177 / 6181
页数：5
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