Identification of genes regulated by the EWS/NR4A3 fusion protein in extraskeletal myxoid chondrosarcoma

被引：10

作者：

Filion, Christine ^{[1
]}

Labelle, Yves ^{[1
,2
]}

机构：

[1] Hop St Francois Assise CHUQ, Ctr Rech, Quebec City, PQ G1L 3L5, Canada

[2] Univ Laval, Fac Med, Quebec City, PQ G1V 0A6, Canada

来源：

TUMOR BIOLOGY | 2012年 / 33卷 / 05期

关键词：

Extraskeletal myxoid chondrosarcoma; Fusion protein; Transcription factor; Target genes; Microarray analyses; Mesenchymal bone marrow stem cells; ORPHAN NUCLEAR RECEPTOR; STEM-CELLS; GAMMA-SYNUCLEIN; ALPHA-SYNUCLEIN; CDNA MICROARRAY; DOWN-REGULATION; BREAST-CANCER; EXPRESSION; TRANSLOCATION; EWS;

D O I：

10.1007/s13277-012-0415-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Approximately 75 % of extraskeletal myxoid chondrosarcoma tumors (EMC) harbor a t(9;22) chromosome translocation generating an EWS/NR4A3 fusion protein that is thought to be instrumental in the tumoral process. Current evidence suggests that one function of the fusion protein is to overexpress target genes. We have generated an in vitro human cellular model in which the fusion protein is expressed in mesenchymal bone marrow stem cells. We have performed microarray analyses of these cells and identified several genes overexpressed in the presence of EWS/NR4A3 which are also overexpressed in EMC tumors. These genes and their products represent potential therapeutic targets for EMC tumors.

引用

页码：1599 / 1605

页数：7

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