SYNTHESIS AND ANTIMICROBIAL SCREENING OF N-[2-(2/4-SUBSTITUTED PHENYL)-1-(5/6 SUBSTITUTED 1H- BENZIMIDAZOL-2-YL)VINYL]BENZAMIDES

被引：0

作者：

Kaushik, Darpan ^{[1
]}

Khan, Suroor A. ^{[1
]}

Chawla, Gita ^{[1
]}

Panda, Bibhu P. ^{[2
]}

机构：

[1] Jamia Hamdard, Div Med Chem, FO Pharm, New Delhi 11062, India

[2] Jamia Hamdard, Microbiol & Biotechnol Div, FO Pharm, New Delhi 11062, India

来源：

ACTA POLONIAE PHARMACEUTICA | 2012年 / 69卷 / 04期

关键词：

benzimidazole; Erlenmeyer-Plochl azlactone synthesis; identifiable strains; minimal inhibitory concentration; two fold dilution technique; BENZIMIDAZOLE DERIVATIVES; ANTIBACTERIAL ACTIVITY; DESIGN;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A series of (benzamidostyryl)benzimidazole derivatives were synthesized by hydrolyzing 2-phenyl-4-(substituted)benzylidene-5-oxazolones, the azlactone precursors in an acidic medium and treating the product with substituted o-phenylenediamine (OPDA) in situ. The structures of the synthesized compounds were confirmed by spectral and elemental analyses. All synthesized compounds were screened for their in vino antimicrobial activities against some identifiable strains. Thereby, it was found that only nitro substituted benzimidazoles exhibited good to moderate antibacterial activity, while other derivatives were devoid of any antimicrobial effect.

引用

页码：629 / 636

页数：8

共 19 条

[1]

[Anonymous], M7A6 NAT COMM CLIN L

[2] Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives [J].

Ansari, K. F. ;

Lal, C. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (10) :4028-4033

[3] Imidazole and benzimidazole derivatives as chemotherapeutic agents [J].

Boiani, M ;

González, M .

MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2005, 5 (04) :409-424

[4] Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives [J].

Cheng, J ;

Xie, JT ;

Luo, XJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (02) :267-269

[5] Green route for the heterocyclization of 2-mercaptobenzimidazole into β-lactum segment derivatives containing -CONH- bridge with benzimidazole:: Screening in vitro antimicrobial activity with various microorganisms [J].

Desai, Krunal G. ;

Desai, Kishor R. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (24) :8271-8279

[6]

Foks H, 2006, KHIM GETEROTSIKL+, P697

[7] Synthesis and antimicrobial activity of some novel phenyl and benzimidazole substituted benzyl ethers [J].

Guven, Ozden Ozel ;

Erdogan, Taner ;

Goker, Hakan ;

Yildiz, Sulhiye .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (08) :2233-2236

[8] 2-Piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities [J].

He, Y ;

Wu, BG ;

Yang, J ;

Robinson, D ;

Risen, L ;

Ranken, R ;

Blyn, L ;

Sheng, S ;

Swayze, EE .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (19) :3253-3256

[9] ANTIBACTERIAL ACTIVITY OF SOME ESSENTIAL OILS AND THEIR COMBINATIONS [J].

JAIN, SR ;

KAR, A .

PLANTA MEDICA, 1971, 20 (02) :118-&

[10] Design, synthesis, and evaluation of 5-sulfamoyl benzimidazole derivatives as novel angiotensin II receptor antagonists [J].

Kaur, Navneet ;

Kaur, Amardeep ;

Bansal, Yogita ;

Shah, Dhvanit I. ;

Bansal, Gulshan ;

Singh, Manjeet .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (24) :10210-10215

← 1 2 →