Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-β1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-α

被引：48
|
作者：
Hui, W [1 ]
Rowan, AD [1 ]
Cawston, T [1 ]
机构：
[1] Newcastle Univ, Sch Med, Dept Rheumatol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
CYTOKINE | 2001年 / 16卷 / 01期
关键词：
cartilage; collagen; IGF-1; TGFbeta; TNFalpha;
D O I：
10.1006/cyto.2001.0950
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumour necrosis factor-alpha (TNF-alpha) was able to promote collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases (MMPs) and could be prevented by transforming growth factor-beta1 (TGF-beta1) or insulin-like growth factor-1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGF-beta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against TNF-alpha -induced destruction. (C) 2001 Academic Press.
引用
收藏
页码：31 / 35
页数：5
相关论文
共 50 条
  • [41] Anabolic actions of IGF-I and TGF-β1 on Interleukin-1β-treated human articular chondrocytes: Evaluation in two and three dimensional cultures
    Seifarth, Claudia
    Csaki, Constanze
    Shakibaei, Mehdi
    HISTOLOGY AND HISTOPATHOLOGY, 2009, 24 (10) : 1245 - 1262
  • [42] Betulin Down Regulates Interleukin-1-α-stimulated Aggrecanases and Matrix Metalloproteinases Gene Expression in Human Chondrocytes.
    Huh, J.
    Back, Y.
    Kim, D.
    Choi, D.
    Lee, J.
    Park, D.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S410 - S410
  • [43] Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells
    Heidinger, M
    Kolb, H
    Krell, HW
    Jochum, M
    Ries, C
    BIOLOGICAL CHEMISTRY, 2006, 387 (01) : 69 - 78
  • [44] Synthesis of type-II phospholipase A(2) by human articular chondrocytes: Modulation by IL-1 beta, TNF alpha and IGF-1.
    Moldovan, M
    Sautet, A
    Humbert, L
    Bereziat, G
    Berenbaum, F
    ARTHRITIS AND RHEUMATISM, 1997, 40 (09): : 581 - 581
  • [45] Expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinase 1 and 2 in inflammation-induced corneal neovascularization
    Ma, DHK
    Chen, JK
    Kim, WS
    Hao, YX
    Wu, HC
    Tsai, RJF
    Hwang, DG
    Zhang, F
    OPHTHALMIC RESEARCH, 2001, 33 (06) : 353 - 362
  • [46] The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes
    Elliott, S
    Hays, E
    Mayor, M
    Sporn, M
    Vincenti, M
    ARTHRITIS RESEARCH & THERAPY, 2003, 5 (05) : R285 - R291
  • [47] The triterpenoid CDDO inhibits expression of matrix metalloproteinase-1, matrix metalloproteinase-13 and Bcl-3 in primary human chondrocytes
    Sarah Elliott
    Ezra Hays
    Michael Mayor
    Michael Sporn
    Matthew Vincenti
    Arthritis Res Ther, 5
  • [48] Gene expression of matrix metalloproteinases 1, 3, and 9 by chondrocytes in osteoarthritic human knee articular cartilage is zone and grade specific
    Freemont, AJ
    Hampson, V
    Tilman, R
    Goupille, P
    Taiwo, Y
    Hoyland, JA
    ANNALS OF THE RHEUMATIC DISEASES, 1997, 56 (09) : 542 - 549
  • [49] Effects of IL-1β, TNF-α, and TGF-β on ciliary beat frequency of human nasal ciliated epithelial cells in vitro
    Rhee, CS
    Hong, SK
    Min, YG
    Lee, CH
    Lee, KS
    Ahn, SH
    Park, KS
    Yi, WJ
    AMERICAN JOURNAL OF RHINOLOGY, 1999, 13 (01): : 27 - 30
  • [50] Gelatinases and their tissue inhibitors during human ovulation:: increased expression of tissue inhibitor of matrix metalloproteinase-1
    Lind, A. -K.
    Dahm-Kahler, P.
    Weijdegard, B.
    Sundfeldt, K.
    Brannstrom, M.
    MOLECULAR HUMAN REPRODUCTION, 2006, 12 (12) : 725 - 736
12345