Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-β1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-α

被引：48
|
作者：
Hui, W [1 ]
Rowan, AD [1 ]
Cawston, T [1 ]
机构：
[1] Newcastle Univ, Sch Med, Dept Rheumatol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
CYTOKINE | 2001年 / 16卷 / 01期
关键词：
cartilage; collagen; IGF-1; TGFbeta; TNFalpha;
D O I：
10.1006/cyto.2001.0950
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumour necrosis factor-alpha (TNF-alpha) was able to promote collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases (MMPs) and could be prevented by transforming growth factor-beta1 (TGF-beta1) or insulin-like growth factor-1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGF-beta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against TNF-alpha -induced destruction. (C) 2001 Academic Press.
引用
收藏
页码：31 / 35
页数：5
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