Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-β1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-α

被引：48
|
作者：
Hui, W [1 ]
Rowan, AD [1 ]
Cawston, T [1 ]
机构：
[1] Newcastle Univ, Sch Med, Dept Rheumatol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
来源：
CYTOKINE | 2001年 / 16卷 / 01期
关键词：
cartilage; collagen; IGF-1; TGFbeta; TNFalpha;
D O I：
10.1006/cyto.2001.0950
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tumour necrosis factor-alpha (TNF-alpha) was able to promote collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases (MMPs) and could be prevented by transforming growth factor-beta1 (TGF-beta1) or insulin-like growth factor-1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGF-beta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against TNF-alpha -induced destruction. (C) 2001 Academic Press.
引用
收藏
页码：31 / 35
页数：5
相关论文
共 23 条
  • [1] Modulation of intracellular reactive oxygen species level in chondrocytes by IGF-1, FGF, and TGF-β1
    Jallali, Navid
    Ridha, Hyder
    Thrasivoulou, Christopher
    Butler, Peter
    Cowen, Timothy
    CONNECTIVE TISSUE RESEARCH, 2007, 48 (03) : 149 - 158
  • [2] Prevention of IGF-1 and TGFβ stimulated type II collagen and decorin expression by bFGF and identification of IGF-1 mRNA transcripts in articular chondrocytes
    Desai, S
    MATRIX BIOLOGY, 2001, 20 (04) : 233 - 242
  • [3] Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver:: regulation by TNF-α and TGF-β1
    Knittel, T
    Mehde, M
    Kobold, D
    Saile, B
    Dinter, C
    Ramadori, G
    JOURNAL OF HEPATOLOGY, 1999, 30 (01) : 48 - 60
  • [4] Differential effects of IGF-1 and TGFβ-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes
    van Osch, GJVM
    van den Berg, WB
    Hunziker, EB
    Häuselmann, HJ
    OSTEOARTHRITIS AND CARTILAGE, 1998, 6 (03) : 187 - 195
  • [5] Expression of proteinase-activated receptors (PAR)-2 in articular chondrocytes is modulated by IL-1β, TNF-α and TGF-β
    Xiang, Y.
    Masuko-Hongo, K.
    Sekine, T.
    Nakamura, H.
    Yudoh, K.
    Nishioka, K.
    Kato, T.
    OSTEOARTHRITIS AND CARTILAGE, 2006, 14 (11) : 1163 - 1173
  • [6] Effects of indomethacin on the production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinases-1 by human articular chondrocytes
    Yamada, H
    Kikuchi, T
    Nemoto, O
    Obata, K
    Sato, H
    Seiki, M
    Shinmei, M
    JOURNAL OF RHEUMATOLOGY, 1996, 23 (10) : 1739 - 1743
  • [7] The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1
    Hayes, Anthony J.
    Ralphs, James R.
    HISTOCHEMISTRY AND CELL BIOLOGY, 2011, 136 (02) : 163 - 175
  • [8] The response of foetal annulus fibrosus cells to growth factors: modulation of matrix synthesis by TGF-β1 and IGF-1
    Anthony J. Hayes
    James R. Ralphs
    Histochemistry and Cell Biology, 2011, 136 : 163 - 175
  • [9] TGF-β1 and IGF-1 influence the re-differentiation capacity of human chondrocytes in 3D pellet cultures in relation to different oxygen concentrations
    Jonitz, Anika
    Lochner, Katrin
    Tischer, Thomas
    Hansmann, Doris
    Bader, Rainer
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2012, 30 (03) : 666 - 672
  • [10] Induction of matrix metalloproteinase-13 gene expression by TNF-α is mediated by MAP kinases, AP-1, and NF-κB transcription factors in articular chondrocytes
    Liacini, A
    Sylvester, J
    Li, WQ
    Huang, WS
    Dehnade, F
    Ahmad, M
    Zafarullah, M
    EXPERIMENTAL CELL RESEARCH, 2003, 288 (01) : 208 - 217
123