Modulation of the expression of matrix metalloproteinase and tissue inhibitors of metalloproteinases by TGF-β1 and IGF-1 in primary human articular and bovine nasal chondrocytes stimulated with TNF-α

被引：48

作者：

Hui, W ^{[1
]}

Rowan, AD ^{[1
]}

Cawston, T ^{[1
]}

机构：

[1] Newcastle Univ, Sch Med, Dept Rheumatol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

CYTOKINE | 2001年 / 16卷 / 01期

关键词：

cartilage; collagen; IGF-1; TGFbeta; TNFalpha;

D O I：

10.1006/cyto.2001.0950

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tumour necrosis factor-alpha (TNF-alpha) was able to promote collagen breakdown from bovine cartilage in explant culture. This release was dependent upon matrix metalloproteinases (MMPs) and could be prevented by transforming growth factor-beta1 (TGF-beta1) or insulin-like growth factor-1. Both growth factors reduced the expression and secretion of collagenase enzymes, and TGF-beta1 induced tissue inhibitor of metalloproteinase production. This study shows for the first time that these anabolic growth factors can protect cartilage against TNF-alpha -induced destruction. (C) 2001 Academic Press.

引用

页码：31 / 35

页数：5

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