PVA bio-nanocomposites: A new take-off using cellulose nanocrystals and PLGA nanoparticles

被引：92
作者：
Rescignano, N. [1 ]
Fortunati, E. [2 ]
Montesano, S. [3 ]
Emiliani, C. [3 ]
Kenny, J. M. [1 ,2 ]
Martino, S. [3 ]
Armentano, I. [2 ]
机构：
[1] ICTP CSIC, Inst Polymer Sci & Technol, Madrid, Spain
[2] UdR INSTM, Mat Engn Ctr, I-05100 Terni, Italy
[3] Univ Perugia, Dept Expt Med & Biochem Sci, I-06100 Perugia, Italy
来源：
CARBOHYDRATE POLYMERS | 2014年 / 99卷
关键词：
Bio-nanocomposite; Poly(vinyl alcohol); Cellulose nanocrystals; Stem cells; POLY(VINYL ALCOHOL); POLYVINYL-ALCOHOL; SILVER NANOPARTICLES; THERMAL-BEHAVIOR; COMPOSITES; WHISKERS; NANOFIBERS; DELIVERY; RELEASE; CELLS;
D O I：
10.1016/j.carbpol.2013.08.061
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The formation of a new generation of hybrid bio-nanocomposites is reported: these are intended at modulating the mechanical, thermal and biocompatibility properties of the poly(vinyl alcohol) (PVA) by the combination of cellulose nanocrystals (CNC) and poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) loaded with bovine serum albumin fluorescein isothiocynate conjugate (FITC-BSA). CNC were synthesized from microcrystalline cellulose by hydrolysis, while ALGA nanoparticles were produced by a double emulsion with subsequent solvent evaporation. Firstly, binary bio-nanocomposites with different CNC amounts were developed in order to select the right content of CNC. Next, ternary PVA/CNC/NPs bio-nanocomposites were developed. The addition of CNC increased the elongation properties without compromising the other mechanical responses. Thermal analysis underlined the nucleation effect of the synergic presence of cellulose and nanoparticles. Remarkably, bio-nanocomposite films are suitable to vehiculate biopolymeric nanoparticles to adult bone marrow mesenchymal stem cells successfully, thus representing a new tool for drug delivery strategies. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：47 / 58
页数：12
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