Chemical composition, angiotensin I-converting enzyme (ACE) inhibitory, antioxidant and antimicrobial activities of the essential oil from south Tunisian Ajuga pseudoiva Rob. Lamiaceae

被引:10
作者
Ben Mansoura, Mohamed [1 ,2 ]
Balti, Rafik [1 ]
Rabaoui, Lotfi [1 ,4 ,5 ]
Bougatef, Ali [3 ]
Guerfel, Mokhtar [1 ]
机构
[1] Univ Gabes, Higher Inst Appl Biol Medenine, Medenine, Tunisia
[2] Univ Monastir, Lab Genet Biodiversite & valorisat Bioressources, Monastir, Tunisia
[3] Univ Sfax, Higher Inst Biotechnol Sfax, Sfax, Tunisia
[4] Univ Tunis El Manar, Fac Sci Tunis, Res Unit Integrat Biol & Evolutionary, Tunis, Tunisia
[5] Funct Ecol Aquat Syst, Tunis, Tunisia
关键词
Ajuga pseudoiva; ACE inhibitory activity; Antibacterial activity; Antioxidant activity; Essential oil; L. ESSENTIAL OIL; AQUEOUS EXTRACT; VITRO ANTIOXIDANT; ANTIFUNGAL ACTIVITIES; PLANT-EXTRACTS; CHINESE HERBS; IVA; ANTIBACTERIAL; DISEASE; PARTS;
D O I
10.1016/j.procbio.2013.02.022
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The essential oil of Ajuga pseudoiva, collected from Tunisia, was analyzed using gas chromatography-mass spectroscopy. Thirty-two compounds accounting for 95.76% of the total oil were identified. Sesquiterpenes were found to be the most abundant components of A. pseudoiva oil. And they were mainly represented by viridiflorol (30.17%), germacrene B (9.26%) (alpha, beta and gamma)-eudesmol (8.11%) and aromadendrene (7.45%). The essential oil of A. pseudoiva showed radical scavengers activity (IC50 = 0.72 mg/mL) and displayed lipid peroxidation inhibitory activity (IC50 = 0.6 mg/mL). A. pseudoiva essential oil was also found to exhibit a dose-dependent ACE inhibitory activity with an IC50 value of 65.5 mu g/mL. Moreover, the antimicrobial activity of the essential oil was tested against 17 species of microorganisms, and the results obtained showed significant antibacterial activity against the Gram-positive and Gram-negative bacteria, with inhibition zones and minimal inhibitory concentration values of 14-32 mm and 84-137 mu g/mL and 6-21 mm and 105-336 mu g/mL, respectively. Higher activity was also found against several fungal strains. Crown Copyright (c) 2013 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:723 / 729
页数:7
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